7 [micro]g/ml (final concentration of KJ in incubation media) is based on the results of pharmacokinetic study of KJ-derived andrographolide
in human blood plasma, where it was detected in concentrations of ~ 0.
sensitizes cancer cells to TRAIL induced apoptosis via p53-mediated death receptor 4 upregulation, Mol Cancer Ther.
Burgos, and entitled, "Andrographolide
: a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease," is summarized as a "robustly detailed discussion of andrographolide
(diterpenoids in the labdane class).
Table 2 (with 3): Percentage of andrographolide
concentration and total andrographolide
content per plant in treatments and control Treatments Retention Andrographolide
Total time concentration andrographolide
(%) content per plant (mg/ plant) Sterilized (Control) 15.
Plant extract andrographolide
blocks the binding of NF-KB transcription factor to the promoter regions of target genes, prevents NF-KB activation and inhibits inflammation.
In 2009, Burgos's team was able to demonstrate this andrographolide
formulation's dramatic anti-rheumatic effects for the first time in humans.
Various active constituents isolated from plants are andrographolide
from Andrographis paniculata, picroliv from Picrorhiza kurroa, phyllanthin and hypophyllanthin from Phyllanthus niruri and methoxy benzoic acid from Capparis spinosa, which have been reported to be antihepatotoxic (5-9).
For example, Andrographis paniculata, which has been used for liver disorders in Ayurveda, offers a solution for skin aging via its anti-inflammatory active agent, andrographolide
The pharmacological effects of the plant are attributed to the presence of the primary active principles, andrographolide
and its derivatives deoxyandrographolide, which have beneficial effects on liver and serum enzymes, anti-inflammatory activity, antipyretic effects and pituitary adrenal cortical activity.
suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.
and 14-deoxy-11,12-didehydroandrographolide are two major constituents in Andrographis paniculata, a component of Anrat.
down-regulates hypoxia-inducible factor-1a in human non-small cell lung cancer A549 cells.