andrographolide


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andrographolide (anˈ·drō·graˑ·f·līd),

n the primary component of a traditional medicinal herb,
Andrographis paniculata, found in Asia and India. It has been used in traditional Chinese and Indian medicine to treat a variety of viral infections and has been found to have an inhibitory effect on HIV. See also Andrographis paniculata.
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Andrographolide.
References in periodicals archive ?
7 [micro]g/ml (final concentration of KJ in incubation media) is based on the results of pharmacokinetic study of KJ-derived andrographolide in human blood plasma, where it was detected in concentrations of ~ 0.
Andrographolide sensitizes cancer cells to TRAIL induced apoptosis via p53-mediated death receptor 4 upregulation, Mol Cancer Ther.
Burgos, and entitled, "Andrographolide: a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease," is summarized as a "robustly detailed discussion of andrographolide and neo-andrographolide (diterpenoids in the labdane class).
Table 2 (with 3): Percentage of andrographolide concentration and total andrographolide content per plant in treatments and control Treatments Retention Andrographolide Total time concentration andrographolide (%) content per plant (mg/ plant) Sterilized (Control) 15.
Plant extract andrographolide blocks the binding of NF-KB transcription factor to the promoter regions of target genes, prevents NF-KB activation and inhibits inflammation.
In 2009, Burgos's team was able to demonstrate this andrographolide formulation's dramatic anti-rheumatic effects for the first time in humans.
Various active constituents isolated from plants are andrographolide from Andrographis paniculata, picroliv from Picrorhiza kurroa, phyllanthin and hypophyllanthin from Phyllanthus niruri and methoxy benzoic acid from Capparis spinosa, which have been reported to be antihepatotoxic (5-9).
For example, Andrographis paniculata, which has been used for liver disorders in Ayurveda, offers a solution for skin aging via its anti-inflammatory active agent, andrographolide.
The pharmacological effects of the plant are attributed to the presence of the primary active principles, andrographolide and its derivatives deoxyandrographolide, which have beneficial effects on liver and serum enzymes, anti-inflammatory activity, antipyretic effects and pituitary adrenal cortical activity.
Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.
Andrographolide and 14-deoxy-11,12-didehydroandrographolide are two major constituents in Andrographis paniculata, a component of Anrat.
Andrographolide down-regulates hypoxia-inducible factor-1a in human non-small cell lung cancer A549 cells.