anabolic steroid

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any of a group of lipids with a complex molecule containing carbon atoms in four interlocking rings forming a hydrogenated cyclopentophenanthrene-ring system; three of the rings contain six carbon atoms each and the fourth contains five. Steroids are important in body chemistry and include steroid hormones such as the gonadal or sex steroids, corticosteroids, glucocorticoids, and mineralocorticoids; vitamins of the D group; and the sterols, including cholesterol, the main building block of the steroid hormones in the body. The cardiac glycosides, a group of compounds derived from certain plants, are partly steroids.
anabolic steroid any of a group of synthetic derivatives of testosterone having pronounced anabolic properties and relatively weak androgenic properties; they are used clinically mainly to promote growth and repair of body tissues in diseases or states promoting catabolism or tissue wasting.
gonadal steroid (sex steroid) a steroid hormone produced by a gonad, such as an androgen, estrogen, or progestational agent.

an·a·bol·ic ster·oid

a compound with androgenic properties that increases muscle mass and stimulated protein production; used to treat emaciation; sometimes used by athletes in an effort to increase size, strength, and endurance of muscle. Examples include methyltestosterone, nandrolone, methandrostenolone, and stanozolol.

anabolic steroid

Any of a group of synthetic steroid hormones that promote the storage of protein and the growth of tissue, sometimes used by athletes to increase muscle size and strength. Nonprescription sale of anabolic steroids was declared illegal in the United States in 1990.

anabolic steroid

Etymology: Gk, anaballein, to build up
any of several compounds derived from testosterone or prepared synthetically to promote general body growth, to oppose the effects of endogenous estrogen, or to promote masculinizing effects. All such compounds cause a mixed androgenic-anabolic effect.
indications It is prescribed in the treatment of aplastic anemia, red-cell aplasia, and hemolytic anemia and in anemias associated with renal failure, myeloid metaplasia, and leukemia.
contraindications It is contraindicated for the palliation of carcinoma of the breast; in pregnancy and serious cardiac, renal, and hepatic diseases; and with known hypersensitivity.
adverse effects Among the most serious adverse effects are acne, growth of facial hair, and hoarsening or deepening of the voice; other masculinizing features are common. Continued use of these compounds in women may also produce prominent musculature, hirsutism, and hypertrophy of the clitoris.

anabolic steroid

A drug or hormone-like substance chemically or pharmacologically related to 17-α-alkylated testosterone that promotes muscle growth, which are commonly abused by athletes. Lipid changes by ASs are more marked with oral stanazol (manufactured for horses) than with IV testosterone; it decreases HDL-C (especially HDL2) and increases hepatic TG lipase (HDL) catabolism.
Children, adolescents with delayed puberty, decreased growth, small penis, hypogonadism, testosterone deficiency, osteoporosis management, aplastic anaemia, endometriosis, angioedema, sports performance enhancement (no longer legal), relief and recovery from common injuries, rehabilitation, weight control, anti-insomnia, and regulation of sexuality, aggression and cognition.

Oral, parenteral.
Metabolic effects
Increased protein synthesis and amino acid consumption, androgenesis, catabolism and gluticocototitosis.
Adverse effects (men)
Breast enlargement (gynecomastia), testicular atrophy, sterility, sperm abnormalities, impotence, prostatic hypertrophy, myocardial hypertrophy and fibrosis, myocardial infarction and fatal arrhythmias, peliosis hepatis, cholestasis, hepatic adenomas, testicular atrophy, peripheral oedema, intracerebral thrombosis.

Adverse effects (women)
Clitoral hypertrophy, beard growth, baldness, deepened voice, decreased breast size.

Adverse effects (men and women)
Aggression and antisocial behavior, increased risk of cardiovascular disease, peliosis hepatis, haemorrhage, jaundice, acne, accelerated bone maturation resulting in short stature, liver tumours (hepatic adenomas and CA) which may regress with abstinence; AS abusers are at an increased risk for HIV transmission, given the common practice of sharing of needles when injecting ASs.

ASs are detectable to 1 parts per billion 4 days after last use if the hormone is water-soluble, or 14 days after use in lipid-soluble compounds.

FDA status
ASs are schedule-III drugs per the Controlled Substances Act.

an·a·bol·ic ster·oid

(an'ă-bol'ik ster'oyd)
Prescription drug used in treatment of the anemias and other disorders involving wasting of the body; it has been abused by some athletes to increase muscle mass; functions in a manner similar to that of the chief male hormone, testosterone. Masculinizing effects are minimized by synthetically manipulating chemical structure to emphasize tissue-building, nitrogen-retaining processes.
See also: ergogenic aid
Synonym(s): androgenic steroid.
[G. anabolē, something tossed up, a mound, fr. ana, up + ballein, to throw + steroid]

Anabolic steroid

Drugs, derived from the male sex hormones, which increase the rate of tissue growth. They are best known for increasing the rate of muscle development.
Mentioned in: Antianemia Drugs

an·a·bol·ic ster·oid

(an'ă-bol'ik ster'oyd)
Compound with androgenic properties that increases muscle mass and stimulated protein production; used to treat emaciation; sometimes used by athletes in an effort to increase size, strength, and endurance of muscle. Examples include methyltestosterone, nandrolone, methandrostenolone, and stanozolol.


pertaining to or arising from anabolism.

anabolic steroid
steroids with a tissue-building effect. Testosterone is an example of a natural anabolic steroid with the, sometimes undesirable, effect of causing masculinization. Synthetic steroids are designed to avoid this problem as much as possible. The purpose of their use includes improvement in body weight in old animals and in the young after debilitating disease or major surgery.
References in periodicals archive ?
It is supposed that nandrolone ingested with food would be quickly absorbed and delivered to the liver, at which nandrolone is metabolized into weak anabolic androgenic steroids, while intramuscularly administrated nandrolone would directly go to the testis via the bloodstream and affect gene expression in the testis before nandrolone is converted into weak metabolites.
However, simultaneous intake of a 17-alkylated androgenic steroid such as Oral-Turinabol or mestanolone with contraceptive steroid preparations increased the risk of liver dysfunctions and damages.
The topics include neuropeptide biosynthesis, dynorphins in central nervous system pathology, the influence of anabolic androgenic steroids on dynorphinergic pathways in the rat's brain, angiotensin II receptors and neuroprotection, and classic and nonclassic cases of interactions between opioid ligands and their receptors.
Anabolic androgenic steroids produce dose-dependent increase in left ventricular mass in power athletes, and this effect is potentiated by concomitant use of growth hormone.
The relationship between anabolic androgenic steroids and muscle dysmorphia: A review.
In this issue of Clinical Chemistry, Lootens and coworkers at Ghent University present a novel approach for the study of the metabolism of anabolic androgenic steroids (AASs) [2] (1).
Weekend warriors and high school students also may be using these performance-enhancing drugs, especially androgenic steroids, and physicians need to know the long-term consequences of these agents.
The androgenic steroids are the ones we hear less about.
Anabolic androgenic steroids are synthetic variations of the male hormone testosterone that mimic its effects by having muscle-building (anabolic) and masculinizing (androgenic) characteristics with potentially harmful health consequences.
What are they going to tell their kids when the kids begin questioning them about all the wonderful things that are supposed to happen to people who feed on anabolic androgenic steroids (AAS) and human-growth hormones (HGH)?
Concomitant abuse of anabolic androgenic steroids and human chorionic gonadotrophin impairs spermatogenesis in power athletes.
There is also evidence that the use of androgenic steroids, such as androstenedione, may have long-term adverse health consequences.