Anchoring fibrils | definition of anchoring fibrils by Medical dictionary
type VII collagen fibrils that insert into the basal lamina of the epidermis and bind it down to the underlying dermis.
an·chor·ing fi·brils (ang'kŏr-ing fī'brilz)
Collagen fibrils that insert into the basal lamina of the epidermis and bind it down to the underlying dermis.
References in periodicals archive
Skin in children with DEB lacks anchoring fibrils
that normally connect the epidermal layer of the skin to the dermis causing the skin's layers to separate, blister and slough off at the slightest insult or injury.
The debilitating condition is caused by significantly reduced collagen type 7 protein (col7) production, a key component of the anchoring fibrils
that connect the cutaneous membranes to the dermis of the skin and mucosal tissues in the gastrointestinal tract.
The acquired type (epidermolysis bullosa acquisita) is a chronic autoimmune disorder characterized by the presence of autoantibodies against type VII collagen, which make up the anchoring fibrils
along the dermal-epidermal junction.