anaplastic carcinoma

an·a·plas·tic car·ci·no·ma

carcinoma with an absence of epithelial structural differentiation.

anaplastic carcinoma

An aggressive epithelial malignancy which lacks histologic criteria required to confirm its embryonic lineage. Anaplastic carcinomas often respond poorly to excision, chemotherapy and radiotherapy. They generally lack architectural landmarks and are divided into small cell, intermediate cell, giant cell, spindle cell and mixed cell types, and occur in the lungs, thyroid, oesophagus and elsewhere.
 
Prognosis
Generally poor; 6-month survival is the norm.
 
Aetiology
Unknown; possibly linked to radiation exposure.
References in periodicals archive ?
Fine-needle aspiration cytology revealed clusters of large multinucleated cells suggestive of an anaplastic carcinoma.
Mucinous tumor of the gallbladder with a separate nodule of anaplastic carcinoma.
About 20% of patients with anaplastic carcinoma have had a prior differentiated thyroid cancer, and 20% to 30% have coexisting well-differentiated and anaplastic disease (3-7).
Differential diagnosis of primary thyroid angiosarcoma includes benign vascular lesions such as hemangioma and sclerosing hemangioma and malignant tumors such as thyroid anaplastic carcinoma (3), (11).
Inoculation of cadmium-treated cells into mice produced invasive, metastatic anaplastic carcinoma with myoepithelial components.
Microscopically NHL needs to be differentiated from anaplastic carcinoma and the solid variant of lobular carcinoma.
Many cases are misidentified as anaplastic carcinoma, poorly differentiated or insular thyroid carcinoma, follicular carcinoma, or Hurthle cell neoplasms, Dr.
OXiGENE's Combretastatin A4 Prodrug (CA4P) will be studied in combination with the chemotherapy drugs doxorubicin/cisplatin and radiation in patients with newly diagnosed anaplastic carcinoma of the thyroid (ATC).
It may also arise from a long-standing goiter or a pathologic lesion with a focus of anaplastic carcinoma in the thyroid gland.