anaplastic carcinoma

an·a·plas·tic car·ci·no·ma

carcinoma with an absence of epithelial structural differentiation.

anaplastic carcinoma

An aggressive epithelial malignancy which lacks histologic criteria required to confirm its embryonic lineage. Anaplastic carcinomas often respond poorly to excision, chemotherapy and radiotherapy. They generally lack architectural landmarks and are divided into small cell, intermediate cell, giant cell, spindle cell and mixed cell types, and occur in the lungs, thyroid, oesophagus and elsewhere.
 
Prognosis
Generally poor; 6-month survival is the norm.
 
Aetiology
Unknown; possibly linked to radiation exposure.
References in periodicals archive ?
However, no case of medullary or anaplastic carcinoma was diagnosed in our study (Fig.
Out of these 7 patients with confirmed malignancy, four had papillary carcinoma; two had follicular carcinomas and one anaplastic carcinoma.
Follicular adenoma is the common benign tumor of thyroid where is papillary carcinoma is the most common thyroid cancer followed by follicular, medullary, anaplastic carcinoma and lymphoma.
Insular and anaplastic carcinoma of the thyroid: a 45-year comparative study at a single institution and a review of the significance of p53 and p21.
The cytological evaluation diagnosed 25 (50%) cases of nodular goiters, 10 (20%) cases of colloid goiters, 6 (12%) cases of Hashimoto's thyroiditis and 1 case (2%) each of anaplastic carcinoma and papillary thyroid carcinoma.
Differential diagnosis of primary thyroid angiosarcoma includes benign vascular lesions such as hemangioma and sclerosing hemangioma and malignant tumors such as thyroid anaplastic carcinoma (3), (11).
Inoculation of cadmium-treated cells into mice produced invasive, metastatic anaplastic carcinoma with myoepithelial components.
Microscopically NHL needs to be differentiated from anaplastic carcinoma and the solid variant of lobular carcinoma.
Many cases are misidentified as anaplastic carcinoma, poorly differentiated or insular thyroid carcinoma, follicular carcinoma, or Hurthle cell neoplasms, Dr.