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anaplasia

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anaplasia /ana·pla·sia/ (-pla´zhah) dedifferentiation; loss of differentiation of cells and of their orientation to one another and to their axial framework and blood vessels, a characteristic of tumor tissue.anaplas´tic
an·a·pla·sia (n-plzh)
n.
Reversion of cells to an immature or a less differentiated form, as occurs in most malignant tumors.

anaplasia
[an′əplā′zhə]
Etymology: Gk, ana + plassein, to shape
a change in the structure and orientation of cells, characterized by a loss of differentiation and reversion to a more primitive form. Anaplasia is characteristic of malignancy. Compare aplasia. anaplastic, adj.

anaplasia [an″ah-pla´zhah]
loss of differentiation of cells and their orientation to each other, a characteristic of tumor cells; called also dedifferentiation and undifferentiation.

anaplasia (an´plā´zh),
n a regressive change in cells toward a more primitive or embryonic cell type. It is a prominent characteristic of malignancy in tumors.

anaplasia
loss of differentiation of cells, an irreversible alteration in adult cells toward more primitive (embryonic) cell types; a characteristic of tumor cells.


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1) The term "dedifferentiated" implies that a portion of cells from the chondrosarcoma have degenerated into a high-grade malignant form that is characterized by pleomorphism, anaplasia, hypercellularity, and increased mitoses.
Based on their cellularity and degree of anaplasia, chondrosarcomas are classified as either low-, medium-, or high-grade tumors.
Nuclear anaplasia can be seen, but mitotic figures are rare.
 
 
 
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