anaphase


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anaphase

 [an´ah-fāz]
the third stage of division of the nucleus of a cell in either meiosis or mitosis.

an·a·phase

(an'ă-fāz),
The stage of mitosis or meiosis in which the chromosomes move from the equatorial plate toward the poles of the cell. In mitosis a full set of daughter chromosomes (46 in humans) moves toward each pole. In the first division of meiosis one member of each homologous pair (23 in humans), consisting of two chromatids united at the centromere, moves toward each pole. In the second division of meiosis the centromere divides and the two chromatids separate with one moving to each pole.
[G. ana, up, + phasis, appearance]

anaphase

/ana·phase/ (an´ah-fāz) the third stage of division of the nucleus in either meiosis or mitosis.

anaphase

(ăn′ə-fāz′)
n.
The stage of mitosis and meiosis in which the chromosomes move to opposite ends of the nuclear spindle.

anaphase

[an′əfāz]
Etymology: Gk, ana + phainein, to appear
the third of four stages of division of the nucleus in mitosis and in each of the two divisions of meiosis. In anaphase of mitosis and of the second meiotic division, the centromeres divide, and the two chromatids, which are arranged along the equatorial plane of the spindle, separate and move to the opposite poles of the cell, forming daughter chromosomes. In anaphase of the first meiotic division, the pairs of homologous chromosomes separate from each other and move intact to the opposite poles of the cell. See also cytokinesis, interphase, meiosis, metaphase, mitosis, prophase, telophase.
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Anaphase

an·a·phase

(an'ă-fāz)
The stage of mitosis or meiosis in which the chromosomes move from the equatorial plate toward the poles of the cell. In mitosis a full set of daughter chromosomes (46 in humans) moves toward each pole. In the first division of meiosis, one member of each homologous pair (23 in humans), consisting of two chromatids united at the centromere, moves toward each pole. In the second division of meiosis, the centromere divides, and the two chromatids separate, with one moving to each pole.
[G. ana, up, + phasis, appearance]

anaphase

A stage in cell division (MITOSIS) in which the separated individual chromosomes migrate to opposite ends of the cell in preparation for the division of the cell into two new individuals.

anaphase

a stage of nuclear division in eukaryotic cells (see EUCORYOTE), occurring once in MITOSIS and twice in MEIOSIS. The main process involved is the separation of chromosomal material to give two groups of chromosomes which will eventually become new cell nuclei. This important step is controlled by SPINDLE MICROTUBULES (or fibres) which run from the organizing centre at each pole to every chromosome, the point of attachment being the kinetochore of the CENTROMERE (see METAPHASE).Various theories for chromosomal movement have been put forward, including:
  1. active repulsion of chromosomes,
  2. the idea that when sliding past each other the microtubules may act as tiny muscles (the ‘sliding filament’ theory), and
  3. a suggestion that the microtubules are disassembled at the poles, so ‘reeling in’ the attached chromosomes.

anaphase

the third stage of division of the nucleus of a cell in either meiosis or mitosis.
References in periodicals archive ?
Number of anaphases is changed differently in different concentrations and treatment.
For instance, the sister chromatids do not separate at the anaphase stage of mitosis in the case of mutants that fail to undergo cleavage of cohesion (Hodges et al.
Normal Multipolar fragments Anaphase Anaphase 1 + - - 2 + - - 3 + - - 4 + - - 5 + - - 6 + - - 7 + - - Sample No.
220,221) Finally, a combination of techniques for the detection of chromosomal alterations (FISH, analysis of telomere length and anaphase bridging) in endoscopic biopsies achieved a sensitivity and specificity greater than 90% in identifying individuals at risk for progression to dysplasia.
The genotoxic effects that were observed in the present study included, lagging chromosomes and chromosomes bridges at anaphase and multipolar anaphases and telophases.
CENP-E is a mitotic kinesin directly involved in coupling the mechanics of mitosis with the mitotic checkpoint signaling machinery, regulating cell-cycle transition from metaphase to anaphase.
In 1998 he made international headlines when Israel's president, Ezer Weizman, questioned a section of his Anaphase (1993).
This result, in conjunction with the electric dipole nature of microtubule subunits, is sufficient to explain and unify the basic events of cell division: (1) assembly of asters, (2) motion of asters to poles, (3) poleward motion of chromosomes during anaphase A, (4) anaphase B cell elongation, and (5) cytokinesis.
Anaphase bridges, sticky and knotted chromosomes, multipolar spindles, polyploidy and C-metaphases were encountered in 31-1000 ppm treated lots as qualitative mutations.
gene heredity mutation mitosis embryo allele helix clone sequence polymer autosome phenotype recessive metaphase locus polymerase telophase oligonucleotide geneticist interphase prophase phage bacteriophage chromomere transduction transformation nucleus Mendelian genome meiosis chromosome recombinant pedigree plasmid vector replicon nucleosome chromatography zygote centromere anaphase genotype endonuclease backcross exonuclease polyploidy diakinesis cytogenetics crossover segregate codominance dominance translocation nucleolus
This movement marks the stage of mitosis known as anaphase.
The discovery, titled "Prostate specific membrane antigen associates with anaphase promoting complex and induces chromosomal instability," is outlined in the July issue of Molecular Cancer Therapeutics, an American Association for Cancer Research journal and provides new insights into therapeutic benefit for patients with advanced prostate cancer.