anal intraepithelial neoplasia
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Related to anal intraepithelial neoplasia: Endometrial Intraepithelial Neoplasia, Prostatic intraepithelial neoplasia, Vulvar intraepithelial neoplasia
anal intraepithelial neoplasiaA carcinoma in situ of the anorectal mucosa that is embryologically, histologically, and pathologically analogous to cervical intraepithelial neoplasia, which is linked to HPV infection and divided into low-grade (LG-AIN) and high-grade (HG-AIN) tumours, the latter of which is associated with aggressive squamous cell carcinoma.
Anal HPV infections, receptive anal intercourse, HIV infection and decreased CD4-+ve T cells.
6/11, 31/33/35 and 16/18.
anal intraepithelial neoplasiaAbbreviation: AIN
A precancerous change in the squamous cells of the anus that may eventually develop into anorectal cancer. It is similar to cervical intraepithelial neoplasia in that it is a premalignant lesion that arises in squamous cells, is found primarily in sexually active people, and is associated with human papillomavirus and HIV.Synonym: anal dysplasia; anal squamous intraepithelial lesion
See also: neoplasia