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anagrelide

   Also found in: Wikipedia 0.01 sec.
anagrelide /an·ag·re·lide/ (an-ag´rĕ-līd) an agent used to reduce elevated platelet counts and the risk of thrombosis in the treatment of hemorrhagic thrombocythemia; used as the hydrochloride salt.
Anagrelide
An orphan drug that is approved for treating PV patients on an investigational basis. Anagrelide works by controlling the level of platelets in the blood.
Mentioned in: Polycythemia Vera
anagrelide,
an antiplatelet agent.
indication This drug is prescribed for essential thrombocythemia.
contraindications Known hypersensitivity and hypotension prohibit its use.
adverse effects Life-threatening effects include congestive heart failure, myocardial infarction, myocardiopathy, cardiomegaly, complete heart block, atrial fibrillation, anemia, thrombocytopenia, ecchymosis, and lymphadenoma. Other serious effects include tachycardia, palpitations, arrhythmia, and seizures. Common side effects include orthostatic hypotension and rash.
anagrelide [an-ag´rĕ-līd]
an agent used in the form of the hydrochloride salt to reduce elevated platelet counts and the risk of thrombosis in treatment of hemorrhagic thrombocythemia; administered orally.
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Following an initial medical treatment with nitrates, beta-blockers, angiotensin converting enzyme inhibitors, aspirin, statins, sedatives and continuing anti-platelet therapy with Anagrelide (Thromboreductin[TM]--AOP Orphan Pharmaceuticals, Austria) a coronary angiogram was performed, revealing an irregular 90% stenotic lesion of the proximal left anterior descending (LAD) and first diagonal coronary arteries.
Coronary bypass surgery in essential thrombocytemia / Esansiyel ... by Yorukoglu, Yavuz; Ayli, Meltem; Akgul, Ebru / The Anatolian Journal of Cardiology (Anadolu Kardiyoloji Dergisi)
Background: A 78-year-old male with a history of essential thrombocytosis, who was on chronic anagrelide therapy, presented with a 3-day history of malaise, poor oral intake, abdominal and back pain, and diarrhea.
Abstracts of scientific posters by Southern Medical Journal
Anagrelide hydrochloride is marketed by Shire in the US and Canada under the trademark AGRYLIN(R) and will be marketed in Europe under the trademark XAGRID(R).
SHIRE LICENSES AGRYLIN TO KIRIN PHARMACEUTICAL IN JAPAN by Worldwide Biotech
 
 
 
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