amyotrophic lateral sclerosis type 10

amyotrophic lateral sclerosis type 10

A hereditary neurodegenerative disorder (OMIM:612089) which affects upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis; sensory abnormalities are absent. Death usually occurs within 2 to 5 years.

Molecular pathology
Defects of TARDBP, which encodes a DNA and RNA-binding protein that regulates transcription and splicing, cause amyotrophic lateral sclerosis type 10.
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