Amyloid-precursor protein | definition of amyloid-precursor protein by Medical dictionary
a cell-surface receptor involved with neuritic growth, neuronal adhesion, and axonogenesis; cleavage of amyloid precursor protein by secretases generates beta-amyloid; abnormal synthesis of amyloid precursor protein leads to plaque formation in Alzheimer disease.
References in periodicals archive
The causes for Alzheimer's disease are not known, but dysregulation of amyloid-precursor protein
expression and beta-amyloid clearance is hypothesized (beta-amyloid cascade).
IBL has independently generated monoclonal antibodies that meet Intellect's requirements for "free-end specific antibodies," a property which allows the antibody to discriminate between beta-amyloid and closely related proteins such as the Amyloid-Precursor Protein
that has several important functions in the body.