amyloid precursor protein


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Related to amyloid precursor protein: amyloidosis, Tau protein

amyloid precursor protein

n. Abbr. APP
A protein found in cell membranes that forms beta-amyloid fragments when cleaved by the secretase designated beta.

amyloid precursor protein (APP)

a large transmembrane glycoprotein expressed on the cell surface and of uncertain function; it may be cleaved on the cell surface to a soluble form. Alternatively, cleavage may follow endocytosis and in some cases then yields 40 to 43 abnormal amino acid peptides, which aggregate to form Ab amyloid, associated with Alzheimer's disease.

amyloid precursor protein

Abbreviation: APP
An integral membrane protein concentrated at neuron synapses that is cleaved biochemically into components, one of which is the Alzheimer's disease–associated beta amyloid. Mutations in the gene for APP on chromosome 21 account for less than 5% of early-onset familial Alzheimer's disease.
See also: protein

amyloid precursor protein

A natural brain protein that is coded for on chromosome 21. This protein is related in some way to memory. Point mutations are found in the gene for this protein in people who suffer from a familial form of early-onset ALZHEIMER'S DISEASE. Only a small proportion of cases of Alzheimer's disease, however, are caused in this way. Abnormally folded AMYLOID protein in the form of plaques and tangles occur in brain cells in Alzheimer's disease but also in chronic suppurative states in other parts of the body.
References in periodicals archive ?
The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease," Biochimica et Biophysica Acta--Molecular Basis of Disease, vol.
Furthermore, this family has an undoubtedly pathogenic mutation in the amyloid precursor protein gene resulting in a valine to glycine substitution at APP 717 which co-segregates with the disease.
Beta amyloid precursor protein site cleaving enzyme (BACE) is believed to be a key enzyme in the production of beta amyloid peptide.
Netrin-1 interacts with amyloid precursor protein and regulates amyloid-[beta] production," Cell Death & Differentiation, vol.
A[beta] is a 38-to-43 amino-acid peptide resulting from proteolytic cleavage of amyloid precursor protein (APP).
The medicine is an oral beta amyloid precursor protein site cleaving enzyme inhibitor.
Kari Stefansson, chief executive officer of deCODE Genetics in Reykjavik, and his colleagues focused on variants of the amyloid precursor protein (APP) gene.
The concurrent discovery that a mutation in the amyloid precursor protein (APP) gene caused early-onset Alzheimer's, coupled with the association of plaque deposition and early Alzheimer's in Down syndrome patients, added weight to the theory (Trends Pharmicol.
The beta amyloid fragments are generated as a product of metabolism from the much larger Amyloid Precursor Protein which is present in most tissues in the body and implicated in numerous important physiological functions.
A-beta forms when enzymes snip a large protein called amyloid precursor protein (APP) into smaller pieces.
They have found that when the amyloid precursor protein (APP), which normally contributes to the growth and maintenance of brain cells, is cut by enzymes called beta secretase and gamma secretase, the fragments of APP create beta-amyloid plaques.
The team, which has been funded by the Alzheimer's Society, developed an antibody which binds to a naturally occurring protein in the brain - amyloid precursor protein (APP) - and prevents the production of A*.