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polyneuropathy |
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polyneuropathy /poly·neu·rop·a·thy/ (-ndbobr-rop´ah-the) neuropathy of several peripheral nerves simultaneously. amyloid polyneuropathy polyneuropathy associated with amyloidosis, of either the primary or the familial type; symptoms may include dysfunction of the autonomic nervous system, carpal tunnel syndrome, and sensory disturbances in the limbs. erythredema polyneuropathy acrodynia. familial amyloid polyneuropathy autosomal dominant amyloid polyneuropathy, associated with familial amyloidosis and most commonly involving a mutant form of the protein transthyretin.; it may be subclassified on the basis of affected kinships or on the basis of symptoms and the biochemical composition of the affected fibrils.
polyneuropathy [-noo͡rop′əthē] Etymology: Gk, polys, many, neuron, nerve, pathos, disease a condition in which many peripheral nerves are afflicted with a disorder. polyneuropathy a disease involving several nerves. See also neuropathy. acute idiopathic polyneuropathy see idiopathic polyradiculoneuritis. distal polyneuropathy of Birman cats a noninflammatory, diffuse loss of myelinated fibers in the distal portions of the central and peripheral nervous systems, resulting in progressive hindlimb ataxia and hypermetria in young Birman kittens. Believed to be inherited as an autosomal recessive trait. familial polyneuropathy see Boxer progressive axonopathy, hereditary neuronal abiotrophy of Swedish Lapland dogs, giant axonal neuropathy. hypoglycemic polyneuropathy associated with hyperinsulinism of β-cell insulinomas; there is generalized muscle weakness, paraparesis and tetraparesis. hypothyroid polyneuropathy a progressive lower motor neuron disease associated with hypothyroidism. idiopathic polyneuropathy see idiopathic polyradiculoneuritis. immune-mediated polyneuropathy may occur in association with systemic lupus erythematosus in dogs. polyneuropathy Chronic inflammatory polyneuropathy, critical illness polyneuropathy, familial amyloidotic polyneuropathy, multiple neuropathy, peripheral neuropathy, polyneuritis, sensorimotor polyneuropathy Neurology The simultaneous
inflammation of the motor and/or sensory components of 2 or more peripheral nerves. See Mononeuropathy. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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FoldRx's
initial pipeline includes a program in clinical development to treat two
genetic diseases, Familial Amyloid Polyneuropathy (FAP) and Familial
Amyloid Cardiomyopathy (FAC), and a discovery program in Parkinson
disease, based on its broad, proprietary yeast-based drug discovery
platform. FoldRx's
initial pipeline includes a program in clinical development to treat two
genetic diseases, Familial Amyloid Polyneuropathy (FAP) and Familial
Amyloid Cardiomyopathy (FAC), and a discovery program in Parkinson
disease, based on its broad, proprietary yeast-based drug discovery
platform. (FoldRx) announced
today that it has initiated a Phase I clinical study with its lead
candidate, Fx-1006A, a small molecule compound with the potential to
treat genetic disorders, such as familial amyloid cardiomyopathy (FAC)
and familial amyloid polyneuropathy (FAP). |
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