amyloid plaque


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amyloid plaque

A pathologic lesion of Alzheimer’s brains, which is characterised by aggregated amyloid staining material.

Pathology
Congo red staining of tissue reveals an apple-green coloured birefringence when viewed with crossed polarising lenses.

amyloid plaque

Neurology A pathologic lesion of Alzheimer's brains characterized by aggregated amyloid staining material. See Alzheimer's disease, Neurofibrillary tangle.
References in periodicals archive ?
All had their brains scanned using a tracer chemical that binds with amyloid plaques so that they show up on the images.
Complete regression of amyloid plaques in middle aged mice and significant reduction of plaques in the cortex and hippocampus of old mice were reported at the end of the study.
sparse to no amyloid plaques are currently present, which is
Researchers in St Louis tested the sleep patterns of 100 people aged 45 to 80, and found that 25% of the participants had evidence of amyloid plaques, which can appear years before the symptoms of Alzheimer's begin.
The major pathologic findings in the AD brain at autopsy are amyloid plaques (extracellular), neurofibrillary tangles (intracellular), and the loss of synaptic connections.
It is believed to stop the spread of amyloid plaques that damage the wiring in the brain and lead to Alzheimer's and other forms of dementia.
When AN-72 was given to mice their immune system attacked it and the amyloid plaque.
In preclinical studies, EVP-0962 has demonstrated a significant reduction in amyloid plaques, which are believed to be a cause of Alzheimer's disease, and reversed behavioral deficits.
Lead study author Bruce Reed, associate director of the UC Davis Alzheimer's Disease Center, said that their study shows that both higher levels of HDL - good - and lower levels of LDL - bad - cholesterol in the bloodstream are associated with lower levels of amyloid plaque deposits in the brain.
Eli Lilly's product will have the ability to detect amyloid plaque and the future commercial availability of an anti-amyloid therapeutic agent will create a clinical need to identify Alzheimer's disease patients with beta-amyloid.
As part of this study, the research team recruited 147 participants (ages 30-89) to undergo cognitive testing, magnetic resonance imaging (MRI) and PET imaging, using Amyvid, a compound that when injected travels to the brain and binds with amyloid proteins, allowing the scientists to visualize the amount of amyloid plaque.
dissolve the amyloid plaques that are present in the brains of patients with