amsacrine


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amsacrine

/am·sa·crine/ (am´sah-krēn) an antineoplastic that inhibits DNA synthesis; used to treat some forms of leukemia.

amsacrine

A topoisomerase inhibitor with antineoplastic activity; it can also intercalate into the DNA of tumour cells, altering major and minor grooves therein, thereby inhibiting DNA replication and transcription by reducing association between the altered DNA and DNA polymerase, RNA polymerase and transcription factors.

Indications
Acute lymphoblastic leukaemia, lymphoma.

Adverse effects
Bone marrow suppression.

amsacrine

A cytotoxic drug used to treat acute myeloid leukaemia. A brand name is Amsidine.
References in periodicals archive ?
Common chemotherapeutic agents that have been implicated in the syndrome of nonhepatic/noncirrhotic hyperammonemia include cytarabine, vincristine, amsacrine, etoposide, L-asparaginase, cyclophosphamide, and 5-fluorouracil in various combinations.
Contract award: delivery of product amsacrine, under ordinance ?
remission induction courses with cytarabine, daunorubicin, and etoposide [ADE] given for 10, 3, and 5 d, respectively, for the 1 st course, and 8, 3, and 5 d, respectively, for the 2nd course, and 2 consolidation courses consisting of amsacrine, cytarabine, etoposide [MACE], and MidAC [mitoxantrone, cytarabine] and triple intrathecal chemotherapy given once after each chemotherapy courses (14).
The chemotherapeutic agents nocodazole and amsacrine cause meiotic delay and non-disjunction in spermatocytes of mice.
Topoisomerase II inhibitors are Amsacrine and Etoposide.
Furthermore, it was shown that ZEN-012 is a catalytic inhibitor of the enzyme topoisomerase II with the same potency as amsacrine.
2] (n = 44) Amsacrine 6 (of 19) adults Systemic clearance (AMSA) with disseminated (CLs) of cancer given 30 [sup.
Semisynthetic Topo II poisons, amsacrine (m-AMSA) and etoposide, stabilise the covalent Topo II-DNA cleavage complex on both DNA strands.
patent for Extra(TM) technology with more specific claims including Taxol(R) (paclitaxel, Bristol-Myers Squibb) and amsacrine, as well as broader coverage of anti-cancer, antibiotic, anti-fungal, vessicant and other chemical cytotoxic agents.
patent in this area, has more specific coverage including Taxol(R) (paclitaxel, Bristol-Myers Squibb) and amsacrine, as well as broader coverage of cancer, antibiotic, anti-fungal, vessicant and other chemical cytotoxic agents.
Notably, teniposide is active against sublines of certain murine leukemias with acquired resistance to cisplatin, doxorubicin, amsacrine,