amplification (redirected from amplify)

amplification /am·pli·fi·ca·tion/ (33000) (am″plĭ-fĭ-ka´shun) the process of making larger, such as the increase of an auditory stimulus, as a means of improving its perception.

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gene amplification  the process by which the number of copies of a gene is increased in certain cells; in humans it is most often seen in malignant cells.

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am·pli·fi·ca·tion (mpl-f-kshn)

n.

1. The process of increasing the magnitude of a variable quantity, especially the magnitude of voltage, power, or current, without altering any other quality.

2. The result of such a process.

3. The process by which genes or DNA sequences are copied in an organism or in the laboratory.

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Amplification

A process by which something is made larger. In clotting, only a very few chemicals are released by the initial injury; they result in a cascade of chemical reactions which produces increasingly larger quantities of different chemicals, resulting in an appropriately-sized, strong fibrin clot.

Mentioned in: Hemophilia

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amplification

[am′plifikā′shən]

Etymology: L, amplificare, to make wider

1 a genetic engineering process in which the amount of plasmid deoxyribonucleic acid (DNA) increases in proportion to the amount of bacterial DNA via treatment with certain substances, including chloramphenicol.

2 the replication in bulk of an entire DNA library. See also polymerase chain reaction. amplify, v.

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amplification [am″plĭ-fĭ-ka´shun]

the process of making larger, such as the increase of an auditory or visual stimulus, as a means of improving its perception.

DNA amplification artificial increase in the number of copies of a particular DNA fragment into millions of copies through replication of the segment into which it has been cloned, a type of nucleic acid amplification.

gene amplification a process by which the number of copies of a gene is increased in certain cells because extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. In humans this process is seen most often in malignant cells.

nucleic acid amplification amplification of a specific nucleic acid sequence, such as to test for presence of a given virus or bacteria in a sample. Types include DNA amplification, ligase chain reaction, and polymerase chain reaction.

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amplification

1. the process of making larger, as the increase of an auditory or visual stimulus, as a means of improving its perception.

2. said of a virus means multiplication; replication.

3. in polymerase chain reaction, the synthesis of multiple copies of a particular nucleic acid template sequence.

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amplification

Molecular biology An in vivo–as in the fragile X syndrome or in vitro–as in cloning or PCR ↑ in the number of copies of a specific gene or DNA sequence of interest. See Cloning, DNA amplification, Exon amplification, Extreme amplification, Gene amplification, Linked linear amplification, PCR, PCR amplification of specific alleles, Solid phase amplification.