amplification

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amplification

 [am″plĭ-fĭ-ka´shun]
the process of making larger, such as the increase of an auditory or visual stimulus, as a means of improving its perception.
DNA amplification artificial increase in the number of copies of a particular DNA fragment into millions of copies through replication of the segment into which it has been cloned, a type of nucleic acid amplification.
gene amplification a process by which the number of copies of a gene is increased in certain cells because extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. In humans this process is seen most often in malignant cells.
nucleic acid amplification amplification of a specific nucleic acid sequence, such as to test for presence of a given virus or bacteria in a sample. Types include DNA amplification, ligase chain reaction, and polymerase chain reaction.

am·pli·fi·ca·tion

(am'pli-fi-kā'shŭn),
The process of making larger, as in increasing an acoustic or visual stimulus to enhance its perception.
[L. amplificatio, an enlarging]

amplification

/am·pli·fi·ca·tion/ (33000) (am″plĭ-fĭ-ka´shun) the process of making larger, such as the increase of an auditory stimulus, as a means of improving its perception.
gene amplification  the process by which the number of copies of a gene is increased in certain cells; in humans it is most often seen in malignant cells.

amplification

(ăm′plə-fĭ-kā′shən)
n.
1. The act or result of amplifying, enlarging, or extending.
2. Physics
a. The process of increasing the magnitude of a variable quantity, especially the magnitude of voltage, power, or current, without altering any other quality.
b. The result of such a process.
3. Genetics The process by which extra copies of a gene or a DNA sequence are formed.

amplification

[am′plifikā′shən]
Etymology: L, amplificare, to make wider
1 (genetic) a process whereby certain targeted sequences of DNA are replicated by the polymerase chain reaction (PCR) in order to produce multiple copies of a single or limited number of genes. Often this refers to increasing the proportion of plasmid DNA relative to the amount of bacterial DNA.
2 the replication in bulk of an entire DNA library. See also polymerase chain reaction. amplify, v.

amplification

An in vivo (as in the fragile X syndrome) or in vitro (as in cloning or PCR) increase in the number of copies of a specific gene or DNA sequence of interest.

amplification

Molecular biology An in vivo–as in the fragile X syndrome or in vitro–as in cloning or PCR ↑ in the number of copies of a specific gene or DNA sequence of interest. See Cloning, DNA amplification, Exon amplification, Extreme amplification, Gene amplification, Linked linear amplification, PCR, PCR amplification of specific alleles, Solid phase amplification.

am·pli·fi·ca·tion

(am'pli-fi-kā'shŭn)
1. The process of making larger, as in increasing an auditory or visual stimulus to enhance its perception.
2. molecular biology Process of increasing the number of nucleic acid copies in a sample to millions within a short period.
[L. amplificatio, an enlarging]

amplification

The production of extra copies of a DNA sequence. These may be within the chromosomal sequence or outside it.

Amplification

A process by which something is made larger. In clotting, only a very few chemicals are released by the initial injury; they result in a cascade of chemical reactions which produces increasingly larger quantities of different chemicals, resulting in an appropriately-sized, strong fibrin clot.
Mentioned in: Hemophilia

amplification

1. the process of making larger, as the increase of an auditory or visual stimulus, as a means of improving its perception.
2. said of a virus means multiplication; replication.
3. in polymerase chain reaction, the synthesis of multiple copies of a particular nucleic acid template sequence.
References in periodicals archive ?
Many researchers studied the prevalence of FGFR1 amplification in patients with NSCLC.
Association between Fibroblast Growth Factor Receptor 1 Amplification and Clinical Characteristics
2), the frequency and the value of the peak of the H/V ratio give information about the value of amplification of the ground vibration, which for [S.
4 meter thickness, which could also influence the amplification of vibration.
Human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene products were quantified by TagMan quantitative PCR for assessment of amplification efficiency, yield of specific amplification products, and reproducibility of the new amplification system.
Amplification efficiency was calculated based on the delta Ct between nonamplified cDNA targets and amplified cDNA, with added consideration of dilution factors, given the relative differences in cDNA concentration.
We were able to demonstrate MYCC amplification in only 4 (5.
A Kaplan-Meier (15) estimate, with standard errors of Peto et al (16) of the survival distributions for patients with and without MYCC amplification (Figure 3), reveals sufficient evidence to conclude that survival among MYCC-amplified patients is poorer than among nonamplified patients (P < .
PCR reactions using Promega's kits: The second method for PCR amplification used the GenePrint[TM] Sex Identification System-Amelogenin (Promega Corporation, Madison, Wisconsin).
A total of 7,600 reference-blood samples from multiple populations was analyzed using the AmpFLSTR[R] Profiler Plus[TM] amplification kit.
It addresses key limitations in the application of nucleic acid amplification outside of the high complexity laboratory.
The Sunrise Amplification Detection System will be available directly from Oncor.