amphotericin B


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Related to amphotericin B: liposomal amphotericin B

amphotericin B

 [am″fo-ter´ĭ-sin]
an antifungal agent and antibiotic used to treat deep-seated fungal infections, especially histoplasmosis, and also to treat cutaneous and mucocutaneous candidiasis. It may be applied topically or administered intravenously or by intracavitary instillation. Anorexia, chills, fever, and headache may occur as side effects. Renal damage with evidence of renal tubular acidosis occurs, but usually clears when the drug is discontinued.

am·pho·ter·i·cin

, amphotericin B (am'fō-tār'i-sin),
An amphoteric polyene antibiotic prepared from Streptomyces nodosus and available as the sodium deoxycholate complex; also a nephrotoxic antifungal agent used extensively in the treatment of systemic mycoses.

amphotericin B

/am·pho·ter·i·cin B/ (-ter´ĭ-sin) an antibiotic derived from strains of Streptomyces nodosus; effective against a wide range of fungi and some species of Leishmania.

amphotericin B

(ăm′fə-tĕr′ĭ-sĭn)
n.
An antibiotic derived from strains of the actinomycete Streptomyces nodosus and used to treat systemic fungal infections.

amphotericin B

[am′fəter′əsin]
an antifungal medication.
indication It is prescribed for topical or systemic use in the treatment of fungal infections.
contraindication Known hypersensitivity prohibits its use.
adverse effects When it is used systemically, among the most serious adverse reactions are anaphylaxis, thrombophlebitis, blood dyscrasia, nephrotoxicity, nausea, and fever; chills and shaking may occur on administration. With topical use, local hypersensitivity reactions are the most common adverse reactions.

amphotericin B

Infectious disease A heptaene macrolide antibiotic produced by the bacteria, Streptomyces nodosus, administered IV Effective against Blastomycosis dermatitidis, Candida, Coccidioides immitis, Cryptococcus neoformans, H capsulatum, Paracoccidioides braziliensis, Torulopsis glabrata Adverse effects Severe–fever, azotemia, nephrotoxicity, chills, headache, anorexia, N&V, diarrhea, kidney damage, BM suppression Lab Hypochromic normocytic anemia, neutropenia See Amphotec, Liposome.

Amphotericin B (Fengizone)

An antifungal medication, prescribed for topical or systemic use in treating fungal infections.

amphotericin B

a nephrotoxic antibiotic used in the treatment of systemic thrush, some types of onychomycosis and leishmaniasis

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.

am·pho·ter·i·cin

, amphotericin B (amfō-teri-sin)
An amphoteric antibiotic and nephrotoxic antifungal agent used extensively to treat systemic mycoses.

amphotericin B

an antifungal antibiotic produced by Streptomyces nodosus, used to treat deep mycotic infections and also to treat cutaneous and mucocutaneous candidiasis. Potential nephrotoxicity limits its use.
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References in periodicals archive ?
The suggested order to continue therapy with lipid complex amphotericin B was incomplete.
Eight serial twofold dilutions of myrtle oil and amphotericin B was prepared and used in the MIC tests.
In patients receiving liposomal amphotericin B, interference in the Synchron LX20 phosphorus assay may lead to unnecessary treatment with phosphorus-binding agents.
20) An association between high rates of cryptococcal IRIS and fluconazole as initial treatment as opposed to amphotericin B has not been demonstrated, but would be consistent with the existing data on risk factors for the development of IRIS.
Bresnik, director of medical affairs for Gilead Sciences, manufacturer of liposomal amphotericin B (Ambisome).
AmBisome has been shown to be significantly less toxic than amphotericin B deoxycholate; however, adverse events may still occur.
We evaluated the synergistic effects of the three essential oils, Melaleuca alternifolia, Origanum vulgare, and Pelargonium graveolens, with Amphotericin B by agar disc diffusion and agar dilution checkerboard titre tests (Rosato et al.
Systemic levels of the drug are expected to be very low, and the hope is that the toxicities that have long prevented the use of intravenous amphotericin B prophylactically will be avoided, he said.
Continued fevers prompted adding amphotericin B to cover fungal pathogens.
Amphotericin B is widely used for the treatment of various systemic fungal infections such as candidiasis.
Salvage therapy response rates were poorest with lipid formulations of amphotericin B, particularly when they were used after failed amphotericin B therapy.