amphotericin


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Related to amphotericin: fluconazole

am·pho·ter·i·cin

, amphotericin B (am'fō-tār'i-sin),
An amphoteric polyene antibiotic prepared from Streptomyces nodosus and available as the sodium deoxycholate complex; also a nephrotoxic antifungal agent used extensively in the treatment of systemic mycoses.

amphotericin

An antibiotic produced from Streptomyces nodosus used to treat systemic fungal infections. The drug is liable to cause kidney damage. Brand names are Ambisome, Amphocil and Fungizone. Amphotericin B is marketed under the brand name Abelcet.

am·pho·ter·i·cin

, amphotericin B (amfō-teri-sin)
An amphoteric antibiotic and nephrotoxic antifungal agent used extensively to treat systemic mycoses.
References in periodicals archive ?
4-6) In much of Africa, fluconazole rather than amphotericin B was, and still is, widely used as initial therapy, for a variety of reasons.
For the 25-mg dose, the peak systemic level of the drug was 20 ng/mL, which is about 2% of the level generally regarded as the threshold of toxicity for amphotericin B, Dr.
He declined further therapy with amphotericin B and was re-admitted two months later with recurrent lesions of the groin, thigh and gluteal region, which were successfully excised.
New antifungal agents are now available; in particular, lipid formulations of amphotericin B, such as amphotericin B colloidal dispersion, amphotericin B lipid complex, and liposomal amphotericin B, are equally effective and less toxic.
In a study conducted by researchers at the National Cancer Institute, the urinary pharmacokinetics and disposition of Nyotran(R) (2, 4 or 6 mg/kg) and amphotericin B (1 mg/kg) were investigated in normal rabbits.
In each dose group, twelve volunteers received a single dose of Bioral Amphotericin B and four received a placebo.
We didn't know he'd had five times the dose of Amphotericin and didn't consider it was an overdose.
Father-of-three Paul Richards, of Walmley, Sutton Coldfield, and Baljit Singh Sunner, of Stechford, suffered severe adverse reactions after wrongly receiving five times the normal dose of fungal infection drug Amphotericin on the Oncology Ward 19 at Heartlands Hospital.
Voriconazole is safer than, and as effective as, the common regimen of amphotericin B followed by fluconazole for treatment of candidemia in non-neutropenic patients, a randomized noninferiority trial suggests.
Uncontrolled coccidioidomycosis meningitis was suspected, and intrathecal amphotericin B treatment was planned.