amphotericin B /am·pho·ter·i·cin B/ (-ter´ĭ-sin) an antibiotic derived from strains of Streptomyces nodosus; effective against a wide range of fungi and some species of Leishmania.
Amphotericin B (Fengizone)
amphotericin B
amphotericin B [am″fo-ter´ĭ-sin]
amphotericin B
am·pho·ter·i·cin B ( m f -t r  -sn)n. An antibiotic derived from strains of the actinomycete Streptomyces nodosus and used in treating systemic fungal infections. |
Amphotericin B (Fengizone)
An antifungal medication, prescribed for topical or systemic use in treating fungal infections.
amphotericin B
[am′fəter′əsin]
an antifungal medication.
indication It is prescribed for topical or systemic use in the treatment of fungal infections.
contraindication Known hypersensitivity prohibits its use.
adverse effects When it is used systemically, among the most serious adverse reactions are anaphylaxis, thrombophlebitis, blood dyscrasia, nephrotoxicity, nausea, and fever; chills and shaking may occur on administration. With topical use, local hypersensitivity reactions are the most common adverse reactions.
amphotericin B [am″fo-ter´ĭ-sin]
an antifungal agent and antibiotic used to treat deep-seated fungal infections, especially histoplasmosis, and also to treat cutaneous and mucocutaneous candidiasis. It may be applied topically or administered intravenously or by intracavitary instillation. Anorexia, chills, fever, and headache may occur as side effects. Renal damage with evidence of renal tubular acidosis occurs, but usually clears when the drug is discontinued.
amphotericin B
an antifungal antibiotic produced by Streptomyces nodosus, used to treat deep mycotic infections and also to treat cutaneous and mucocutaneous candidiasis. Potential nephrotoxicity limits its use.
antifungal agent
Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.
amphotericin B
Infectious disease A heptaene macrolide antibiotic produced by the bacteria, Streptomyces nodosus, administered IV Effective against Blastomycosis dermatitidis, Candida, Coccidioides immitis,
Cryptococcus neoformans, H capsulatum, Paracoccidioides braziliensis, Torulopsis glabrata Adverse effects Severe–fever, azotemia, nephrotoxicity, chills, headache, anorexia, N&V, diarrhea, kidney damage, BM
suppression Lab Hypochromic normocytic anemia, neutropenia See Amphotec, Liposome.
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