amphiregulin


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.

amphiregulin

A 84-residue bifunctional cell growth-modulating glycoprotein encoded by AREG on chromosome 4q13-q21, which inhibits the growth of certain tumours (e.g., epidermal cancer) and stimulates the proliferation of fibroblasts. The carboxy-terminal half of amphiregulin has considerable structural homology with epidermal growth factor and binds to its receptor.
Mentioned in ?
References in periodicals archive ?
The expression of Msx2 and amphiregulin mRNAs, two estrogen-regulated genes (Mallepell et al.
Brisken for suggesting the use of amphiregulin in the gene expression studies.
Khambata-Ford et al (82) found that patients with high gene expression levels of the EGFR ligands epiregulin and amphiregulin in their metastatic tumor lesions were more likely to achieve disease control upon cetuximab treatment.
Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma.
Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus.
The erbB family cell-signaling process uses EGF-like ligands that include cell-signaling transforming growth factor a (TGF-[alpha]), amphiregulin, heparin-binding EGF, epiregulin, heregulin, neuregulin, and betacellulin.