amodiaquine


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amodiaquine

 [am″o-di´ah-kwin]
an antimalarial, administered orally as the hydrochloride salt in the treatment of malaria, especially falciparum malaria.
References in periodicals archive ?
0-3 h] was also performed with 0-3-h postinvasion ring-stage parasites exposed for 6 h to atovaquone (3 [micro]mol/L) or amodiaquine (0.
0 Bupropion hydroxylation CYP2B6 50 Amodiaquine N-deethylation CYP2C8 5 Diclofenac 4'-hydroxylation CYP2C9 10 Omeprazole 5-hydroxyladon CYP2C19 20 Dextromethorphan O-deethylation CYP2D6 5 Chlorzoxazone 6-hydroxylation CYP2E1 50 Midazolam 1-hydroxylation CYP3A4 2.
falciparum malaria cases are artemether-lumefantrine (AM-LF), artesunatemefloquine (AS-MQ), artesunate-sulfadoxine-pyrimethamine (AS-SP), dihydroartemisinin-piperaquine, and artesunate amodiaquine (2).
7 million treatments of Sanofi's ArteSunate AmodiaQuine Winthrop (ASAQ Winthrop, fixed dose artemisinin-based combination therapy), manufactured with semisynthetic artesunate in Morocco, are being shipped from Sanofi's distribution center to Burkina Faso, Burundi, Democratic Republic of the Congo, Liberia, Niger, and Nigeria over the next few months.
In KZN, AL was selected as the preferred ACT as there was no established resistance to the partner drug, lumefantrine, unlike SP or amodiaquine.
Professor Mueller said the most effective drug combination in the trial was the long-lasting antimalarials sulfadoxine/pyrimethamine and amodiaquine (SP-AQ), which act against the two most lethal species of malaria parasite, Plasmodium falciparum and Plasmodium vivax.
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.
Antimalarial drugs include chloroquine, amodiaquine, pyrimethamine, sulfonamides, quinine, quinidine, tetracyclines, mefloquine, and artemisinin (usually in combination with other anti-malarials).
The study concerned versions of such widely used and trusted medications as sulfadoxine-pyrimethamine, amodiaquine, mefloquine, artesunate, artemether, dihydroartemisinin and artemether-lumefantrine fixed-dose combinations.
Sensitivity status of Plasmodium falciparum to chloroquine, amodiaquine, quinine, mefloquine and sulfadoxine/pyremethamine in a tribal population of District Sundergarh, Orissa.
As a response to increasing levels of resistance to antimalarial medicines, the WHO recommended that all countries experiencing resistance to conventional monotherapies, such as chloroquine, amodiaquine or sulphadoxine-pyrimethamine, should use combination therapies, preferably those containing artemisinin derivatives (ACTs--artemisinin-based combination therapies) for falciparum malaria (37).
Study participants were randomised to receive 1 of 3 combination therapies (amodiaquine plus sulphadoxine-pyrimethamine, amodiaquine plus artesunate or artemether-lumefantrine) when diagnosed with their first episode of uncomplicated malaria.