amniotic fluid embolism


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

amniotic fluid embolism

Etymology: Gk, amnion; L, fluere, to flow; Gk, embolos, plug
a quantity of amniotic fluid that enters the maternal blood system during labor and/or delivery and becomes lodged in a vessel. It is usually fatal to the mother if it is a pulmonary embolism.

amniotic fluid embolism

A condition resulting from a traumatic delivery and “injection” of amniotic fluid containing lanugo, squames, mucus and debris into the opened maternal circulation, which communicates with the amniotic fluid.
 
Aetiology
Idiopathic; predisposed to by the high intrauterine pressure that allows amniotic fluid to pass into the maternal venous circulation, where the meconium is toxic to the mother, potentially causing DIC.
 
Clinical findings
Acute shortness of breath, hypertension and rapid progression to cardiac arrest, leading to reduced cardiorespiratory perfusion and coma; those who survive this first phase pass to a haemorrhagic phase, which is characterised by shivering, coughing, vomiting and dysgeusia.

Incidence
1:80,000 deliveries.
 
Diagnosis
Made on clinical grounds, given the difficulty in identifying squames.

Mortality
26–80%.

IHC
LP34 is a better stain than Cam 5.2 or AE1/AE3, as the latter can stain alveolar epithelial cells.

amniotic fluid embolism

Obstetrics A condition resulting from a traumatic delivery and 'injection' of amniotic fluid containing lanugo, squames, mucus and debris into the opened maternal circulation, which communicates with the amniotic fluid Incidence 1:80,000 deliveries Etiology Idiopathic, predisposed to by the high intrauterine pressure that allows amniotic fluid to pass into the maternal venous circulation, where the meconium is toxic to the mother, potentially causing DIC Mortality ±80%. See Embolism.

amniotic fluid embolism

The entry of amniotic fluid through a tear in the placental membranes into the maternal circulation. This rare event may occur at any gestational age, but most commonly during labor, delivery or in the immediate postpartum period. The contents of the fluid (e.g., shed fetal cells, meconium, lanugo, vernix) may produce pulmonary or cerebral emboli. Cardiac arrest and disseminated intravascular coagulation (DIC) commonly occur. Maternal death is a frequent complication

Symptoms

Chest pain, dyspnea, cyanosis, tachycardia, hemorrhage, hypotension, or shock are potential symptoms. Amniotic fluid embolism is frequently fatal.

See also: embolism
References in periodicals archive ?
The difference is that the respiratory distress and cardiac collapse resulting from amniotic fluid embolism occur before the onset of seizures, he said.
John Sullivan, an obstetrical anesthesiologist at Northwestern University, Chicago, commented in particular on amniotic fluid embolism, a "terrifying condition" for which published mortality rates have ranged from as low as 20% to as high as 80%.
Mr Balmain agreed with the pathologist that an 'extraordinarily rare' amniotic fluid embolism had caused Mrs Clift's death, which he ruled was due to natural causes.
He had been told immediately afterwards that she had died from an amniotic fluid embolism, the inquest heard.
Experts in their fields have written chapters discussing general anaesthesia and associated intubation and aspiration, regional anaesthesia, haemorrhage, hypertension, cardiac disease, thromboembolism, amniotic fluid embolism, sepsis and intensive care.
The use of Cytotec[R] in labor is associated with the increased risk of amniotic fluid embolism (AFE), which is now the leading cause of maternal death in the United States.
Dr Andrew Booth, consultant obstetrician and gynaecologist at Scarborough Hospital, said the amniotic fluid embolism was "a very rare complication".
The dangers of partial-birth abortion to women include abruption of the placenta, amniotic fluid embolism, a ruptured uterus which could lead to hysterectomy or additional other major surgical procedures, and cervical incompetence, making it difficult to carry future pregnancies to term.
She had problems with coagulation, probably associated with an amniotic fluid embolism,'' Carrier said.
The Order's autopsy concluded that Zogheib died due to Amniotic Fluid Embolism, a rare condition that is often fatal.
However, the three complications discussed here - amniotic fluid embolism, ruptured uterus, and peripartum cardiomyopathy - are conditions that can happen to otherwise young, healthy women.