aminotransferases


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Related to aminotransferases: aspartate aminotransferase, Transaminases

aminotransferases

Enzymes present in liver cells which are released into the blood in liver disease, such as HEPATITIS, that damages liver cells. The most important are aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Measurement of the levels of these enzymes in the blood is a valuable test of liver damage.
References in periodicals archive ?
Plasma enzyme activities of alanine aminotransferase and aspartate aminotransferase were determined using commercial kits (Zhongsheng Bio-Technology and Science Inc.
The primary endpoint of the trial was the incidence of serum aminotransferase concentrations greater than 3xULN during the 12-week evaluation period that were related to ambrisentan and resulted in discontinuation of drug.
She continued to have good response, with the exception of an episode of diarrhea and elevated aminotransferases (ALT, 84 U/L; and AST, 41 U/L), which was attributed to the use of antibiotic for a tooth abscess.
Other hepatic causes for increases in aminotransferases include hemochromatosis, nonalcoholic fatty liver disease, and Wilson disease.
A new marker of apoptotic caspase activation in sera may provide a sensitive method for detecting patients with chronic hepatitis C virus infection who have significant liver fibrosis but have normal aminotransferase levels, reported Heike Bantel, M.
1) reporting that higher serum alanine aminotransferase (ALT) concentrations, within the reference interval, independently predicted the incidence of nonalcoholic fatty liver disease (NAFLD) during a mean follow-up of 2.
Recent data from the Third National Health and Nutrition Examination Survey (1988-1994) suggest that abnormal aminotransferase values are present in about 8% of the U.
A high precirrhosis body mass index, type 2 diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, and normal levels of aminotransferases were far more likely to accompany cryptogenic cirrhosis than to be seen among 115 controls with hepatocellular carcinoma associated with alcoholic or viral cirrhosis (Gastroenterology 123[7]:134-40, 2002).
In the Letairis full prescribing information, for all Letairis-treated patients (n=483), the 12-week incidence of aminotransferases greater than three times ULN was 0.
3 percent) placebo patients had liver aminotransferases (ALT or AST) elevations greater than three times the upper limit of normal (ULN) compared to zero patients in the ambrisentan group.
Elevations of liver aminotransferases have been reported with Letairis and serious liver injury has been reported with related drugs.