Plasma enzyme activities of alanine aminotransferase
and aspartate aminotransferase
were determined using commercial kits (Zhongsheng Bio-Technology and Science Inc.
The primary endpoint of the trial was the incidence of serum aminotransferase
concentrations greater than 3xULN during the 12-week evaluation period that were related to ambrisentan and resulted in discontinuation of drug.
She continued to have good response, with the exception of an episode of diarrhea and elevated aminotransferases
(ALT, 84 U/L; and AST, 41 U/L), which was attributed to the use of antibiotic for a tooth abscess.
Other hepatic causes for increases in aminotransferases
include hemochromatosis, nonalcoholic fatty liver disease, and Wilson disease.
A new marker of apoptotic caspase activation in sera may provide a sensitive method for detecting patients with chronic hepatitis C virus infection who have significant liver fibrosis but have normal aminotransferase
levels, reported Heike Bantel, M.
Elevations in aminotransferases
require close attention.
1) reporting that higher serum alanine aminotransferase
(ALT) concentrations, within the reference interval, independently predicted the incidence of nonalcoholic fatty liver disease (NAFLD) during a mean follow-up of 2.
Recent data from the Third National Health and Nutrition Examination Survey (1988-1994) suggest that abnormal aminotransferase
values are present in about 8% of the U.
A high precirrhosis body mass index, type 2 diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, and normal levels of aminotransferases
were far more likely to accompany cryptogenic cirrhosis than to be seen among 115 controls with hepatocellular carcinoma associated with alcoholic or viral cirrhosis (Gastroenterology 123:134-40, 2002).
In the Letairis full prescribing information, for all Letairis-treated patients (n=483), the 12-week incidence of aminotransferases
greater than three times ULN was 0.
3 percent) placebo patients had liver aminotransferases
(ALT or AST) elevations greater than three times the upper limit of normal (ULN) compared to zero patients in the ambrisentan group.
Elevations of liver aminotransferases
have been reported with Letairis and serious liver injury has been reported with related drugs.