aminopterin


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aminopterin

Oncology A folic acid antagonist and inhibitor of dihydrofolate reductase; it is a potent cytotoxic agent fomerly used to manage leukemia; it has been replaced by MTX. See Methotrexate.

aminopterin

(am-ĭ-nop′tĕr-ĭn)
A folic acid antagonist used to treat acute leukemia.
References in periodicals archive ?
The federal government prohibits using aminopterin for killing rodents in the United States.
and The University of Medicine and Dentistry of New Jersey (UMDNJ) announced today that there was no evidence of Aminopterin in the tissues of animals who had died from consuming food from Menu Foods, the manufacturer of the many brands of dog and cat food that are currently the subject of a nationwide recall.
The fused cells were cultured with 96-well culture plates (Nunc) in RPMI 1640 (Nissui) containing fetal bovine serum, hypoxanthine, aminopterin, and thymidine.
Initiation of a Phase II trial of aminopterin for treatment of recurrent endometrial cancer.
PT-523, Hudson Health Sciences' lead product, is a novel multi-targeted antifolate anti-cancer drug that is a water-soluble, non-polyglutamatable, type-B analogue of aminopterin.
2] in DMEM (Eurobio) supplemented with 100 mL/L heat-inactivated fetal calf serum (FCS; BioWhittaker), 2 mmol/L glutamine, and 50 mL/L hypoxanthine aminopterin thymidine (FCS medium).
Also during the quarter, ILEX initiated a Phase II clinical trial of aminopterin in patients with persistent and recurrent endometrial cancer who have failed prior therapy.
Phase II studies of aminopterin and Phase I trials of ILX23-7553 and SR-45023A (APOMINETM) continued during the quarter.
First studied in 1948, aminopterin was the first drug to demonstrate the effectiveness of folate inhibition for cancer therapy.
Production of functional human T-T hybridomasin selection medium lacking aminopterin and thymidine.