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aminopterin |
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aminopterin Oncology A folic acid antagonist and inhibitor of dihydrofolate reductase; it is a potent cytotoxic agent fomerly used to manage leukemia; it has been replaced by MTX. See Methotrexate. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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* In utero exposure to aminopterin, an antagonist of folic acid,
has been associated with anencephaly, meningocele, hydrocephalus, and
cleft lip and palate (Thiersch 1952; Warkany et al. Talotrexin is
a novel, non-classical antifolate that is a water-soluble,
non-polyglutamatable analogue of aminopterin. -- Discontinuation of the development of aminopterin, an
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