The federal government prohibits using aminopterin
for killing rodents in the United States.
and The University of Medicine and Dentistry of New Jersey (UMDNJ) announced today that there was no evidence of Aminopterin
in the tissues of animals who had died from consuming food from Menu Foods, the manufacturer of the many brands of dog and cat food that are currently the subject of a nationwide recall.
Discontinuation of the development of aminopterin
PT-523 is a novel, non-classical antifolate that is a water-soluble, nonpolyglutamatable analogue of aminopterin
The fused cells were cultured with 96-well culture plates (Nunc) in RPMI 1640 (Nissui) containing fetal bovine serum, hypoxanthine, aminopterin
, and thymidine.
Initiation of a Phase II trial of aminopterin
for treatment of recurrent endometrial cancer.
PT-523, Hudson Health Sciences' lead product, is a novel multi-targeted antifolate anti-cancer drug that is a water-soluble, non-polyglutamatable, type-B analogue of aminopterin
2] in DMEM (Eurobio) supplemented with 100 mL/L heat-inactivated fetal calf serum (FCS; BioWhittaker), 2 mmol/L glutamine, and 50 mL/L hypoxanthine aminopterin
thymidine (FCS medium).
Also during the quarter, ILEX initiated a Phase II clinical trial of aminopterin
in patients with persistent and recurrent endometrial cancer who have failed prior therapy.
Phase II studies of aminopterin
and Phase I trials of ILX23-7553 and SR-45023A (APOMINETM) continued during the quarter.
First studied in 1948, aminopterin
was the first drug to demonstrate the effectiveness of folate inhibition for cancer therapy.
Production of functional human T-T hybridomasin selection medium lacking aminopterin