aminoacyl-tRNA synthetases


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a·mi·no·ac·yl-tRNA syn·the·tas·es

enzymes catalyzing the formation of a specific aminoacyl-tRNA from an amino acid and adenosine 5'-triphosphate with the concomitant formation of adenosine 5'-monophosphate and pyrophosphate.

tRNA

transfer RNA (ribonucleic acid).

aminoacyl-tRNA
transfer RNA to which its specific amino acid has been coupled by its specific aminoacyl-tRNA synthetase.
aminoacyl-tRNA binding site
one of two tRNA binding sites on a ribosome that holds the incoming tRNA molecule charged with an amino acid. Called also A site.
aminoacyl-tRNA synthetases
a set of enzymes that couple each of the 20 amino acids to its appropriate tRNA molecule.
initiator tRNA
a special methionine tRNA that binds to the initiation codon AUG that forms part of the initiation complex at the start of mRNA translation.
peptidyl-tRNA binding site
one of two tRNA binding sites on a ribosome that holds the tRNA that is normally linked to the polypeptide chain. Called also P site.
References in periodicals archive ?
Now that we know how AN2690 works, the same approach could be adapted to target other aminoacyl-tRNA synthetases with editing sites, which are also excellent targets for anti-microbial drugs," said Cusack, whose group performed the X-ray crystallography which revealed how AN2690 binds to LeuRS.
Amino acids are covalently attached to their cognate tRNAs through the enzymatic action of aminoacyl-tRNA synthetases.
Cubist received the milestone payment for developing and transferring technology enabling Bristol-Myers Squibb to target specific aminoacyl-tRNA synthetase enzymes.
In the initial phase of the partnership, Pfizer will utilize its diverse chemical library and expertise in high throughput screening to identify lead compounds that inhibit the aminoacyl-tRNA synthetases.