amiloride


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Related to amiloride: furosemide, Amiloride hydrochloride

amiloride

 [ah-mil´o-rīd]
a potassium sparing diuretic, used as the hydrochloride salt, usually in combination with hydrochlorothiazide, in the treatment of edema and hypertension and the prevention and treatment of hypokalemia.

amiloride

/amil·o·ride/ (ah-mil´ah-rīd) a potassium-sparing diuretic used as the hydrochloride salt in the treatment of edema and hypertension and in the prevention and treatment of hypokalemia.

amiloride

Nephrology A drug that blocks the Na+/H+ antiporter, used clinically as a potassium-sparing diuretic. See Diuretics, Potassium-sparing diuretic Pulmonology An aerosolized sodium channel blocker that may slow the progression of pulmonary dysfunction in cystic fibrosis. See Diuretics, Potassium-sparing diuretic.

amiloride

A thiazide DIURETIC drug that acts by reducing reabsorption of sodium, and thus water, in the kidneys. A potassium-sparing diuretic used in the treatment of high blood pressure (HYPERTENSION), HEART FAILURE or other conditions in which excess fluid is retained in the body. The drug is on the WHO official list. Formulated in combination with other drugs under brand names such as Amil-Co, Burinex A, Fru-Co, Frumil, Kalten, Lasoride, Moducren, Moduret 25, Moduretic and Navispare.

diuretics

powerful drugs, often termed 'water tablets', that control hypertension and peripheral oedema; action of some local anaesthetics is antagonized by concomitant use of some diuretics (see Table 1), e.g. aldosterone antagonists (e.g. spironolactone); carbonic anhydrase inhibitors, e.g. acetazolamide; loop diuretics, e.g. furosemide; osmotic diuretics, e.g. mannitol; potassium-sparing diuretics, e.g. amiloride, or in combination with other diuretics; thiazide diuretics, e.g. bendroflumethiazide
Table 1: Principal drug interactions of local anaesthetic agents and other medications
Local anaesthetic agent Proprietary name Principal drug interactionsEffect of interaction
Lidocaine
Xylocaine
Antiarrhythmic agents
Antibacterial agents
Antipsychotics
Antivirals
Beta-blockers
Diuretics
Dolasetron
Ulcer-healing drugs
Increased myocardial depression
Increased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristin
Increased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cycle
Plasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavir
Increased myocardial depression
Increased risk of lidocaine toxicity when given with propranolol
The action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia)
Increased risk of ventricular arrhythmia if lidocaine is given with dolasetron
Plasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine
Bupivacaine
Marcain
Levo-bupivacaine
Chirocaine
Beta-blockersIncreased risk of bupivacaine toxicity when given with propranolol
Increased risk of myocardial depression if given with other antiarrhythmic agents
Prilocaine
Citanest
Antiarrhythmic agents
Antibacterial agents
Increased risk of myocardial depression if given with antiarrhythmic agents
Increased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents
Ropivacaine
Naropin
AntidepressantsMetabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity
Mepivacaine
Scandonest
Drug not listed in the British National Formulary

amiloride

a potassium-sparing diuretic.
References in periodicals archive ?
They were assigned to T2 weeks of amiloride at 10 mg/day, HCTZ at 25 mg/day, or the combination at half-doses, followed by another 12 weeks at twice the dose in all three groups.
Amiloride could, in theory, block the epithelial sodium channels, inhibit sodium reabsorption, increase water in the gel layer and "float" debris, microorganisms out of the respiratory tract via the mucociliary escalator.
2002) Increasing plasma potassium with amiloride shortens the QT interval and reduces ventricular extrasystoles but does not change endothelial function or heart rate variability in chronic heart failure.
Warne's illustrious career has frequently been dogged by controversy and he pulled out of the World Cup in 2003 after testing positive for the banned substances hydrochlorothiazide and amiloride after taking a diuretic given to him by his mother during his recovery from a shoulder injury.
Often a controversial figure, he pulled out of the World Cup in 2003 after testing positive for the banned substances, hydrochlorothiazide and amiloride, after taking a diuretic given to him by his mother as he recovered from a shoulder injury, being banned for 12 months, but returned to the side in 2004.
She had a history of mammary radiation in 1986; arterial hypertension treated with hydrochlorothiazide, amiloride, and timolol since 1979; and depressive disorders treated with fluoxetine (20 mg daily) and zopiclone since April 1997.
Further, we examined myogenic constriction and agonist-induced constriction and dilation in isolated mouse renal interlobar arteries in the presence or absence of the specific DEG/ENaC inhibitors, amiloride and benzamil.
The achievement marks an impressive comeback for Warne, who was banned from cricket for a year in 2003 after testing positive for the banned substances hydrochlorothiazide and amiloride.
For one thing, even though the sodium-channel-blocking drug amiloride impairs salt taste in rodents and some other animals, this effect isn't consistent among all species or even among different strains of rodents.
Warne insists the pill, containing banned substances hydrochlorothiazide and amiloride, was NOT taken to enhance performance but simply to help him lose weight.
Warne's career hangs in the balance after he tested positive for diuretics, hydrochlorothiazide and amiloride, prohibited because of their qualities as masking agents for steroids.