amiloride


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Related to amiloride: furosemide, Amiloride hydrochloride

amiloride

 [ah-mil´o-rīd]
a potassium sparing diuretic, used as the hydrochloride salt, usually in combination with hydrochlorothiazide, in the treatment of edema and hypertension and the prevention and treatment of hypokalemia.

amiloride

/amil·o·ride/ (ah-mil´ah-rīd) a potassium-sparing diuretic used as the hydrochloride salt in the treatment of edema and hypertension and in the prevention and treatment of hypokalemia.

amiloride

Nephrology A drug that blocks the Na+/H+ antiporter, used clinically as a potassium-sparing diuretic. See Diuretics, Potassium-sparing diuretic Pulmonology An aerosolized sodium channel blocker that may slow the progression of pulmonary dysfunction in cystic fibrosis. See Diuretics, Potassium-sparing diuretic.

amiloride

A thiazide DIURETIC drug that acts by reducing reabsorption of sodium, and thus water, in the kidneys. A potassium-sparing diuretic used in the treatment of high blood pressure (HYPERTENSION), HEART FAILURE or other conditions in which excess fluid is retained in the body. The drug is on the WHO official list. Formulated in combination with other drugs under brand names such as Amil-Co, Burinex A, Fru-Co, Frumil, Kalten, Lasoride, Moducren, Moduret 25, Moduretic and Navispare.

diuretics

powerful drugs, often termed 'water tablets', that control hypertension and peripheral oedema; action of some local anaesthetics is antagonized by concomitant use of some diuretics (see Table 1), e.g. aldosterone antagonists (e.g. spironolactone); carbonic anhydrase inhibitors, e.g. acetazolamide; loop diuretics, e.g. furosemide; osmotic diuretics, e.g. mannitol; potassium-sparing diuretics, e.g. amiloride, or in combination with other diuretics; thiazide diuretics, e.g. bendroflumethiazide
Table 1: Principal drug interactions of local anaesthetic agents and other medications
Local anaesthetic agent Proprietary name Principal drug interactionsEffect of interaction
Lidocaine
Xylocaine
Antiarrhythmic agents
Antibacterial agents
Antipsychotics
Antivirals
Beta-blockers
Diuretics
Dolasetron
Ulcer-healing drugs
Increased myocardial depression
Increased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristin
Increased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cycle
Plasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavir
Increased myocardial depression
Increased risk of lidocaine toxicity when given with propranolol
The action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia)
Increased risk of ventricular arrhythmia if lidocaine is given with dolasetron
Plasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine
Bupivacaine
Marcain
Levo-bupivacaine
Chirocaine
Beta-blockersIncreased risk of bupivacaine toxicity when given with propranolol
Increased risk of myocardial depression if given with other antiarrhythmic agents
Prilocaine
Citanest
Antiarrhythmic agents
Antibacterial agents
Increased risk of myocardial depression if given with antiarrhythmic agents
Increased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents
Ropivacaine
Naropin
AntidepressantsMetabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity
Mepivacaine
Scandonest
Drug not listed in the British National Formulary

amiloride

a potassium-sparing diuretic.
References in periodicals archive ?
Amiloride was administered 45 min before, and aspirin was administered 1 h before the nociceptive stimulus which was 0.
sup][43] An increased volume of the bladder, resulting in an augment of the hydrostatic pressure of endothelia of bladder, could induce improved inward whole-cell current which is partly abolished by amiloride.
The combination of amiloride and KCl has been successfully used in the past (3).
Further, based on our experience, the use of amiloride during pregnancy was not associated with any adverse effects on the mother or the fetus.
Interestingly, the inhibitory effect of high salt on NO production was significantly restored by amiloride in HUVECs (Figures 3(c) and 3(d)).
But the PATHWAY-3 trial demonstrates that, with the half-dose combination approach, amiloride cancels those side effects, while hydrochlorothiazide (HCTZ) neutralizes amiloride's tendency to boost serum potassium, he explained.
7 mm Hg with amiloride monotherapy, by 14 mm Hg with HCTZ, and by 17.
Attenuation of pulmonary arterial smooth muscle cell proliferation following hypoxic pulmonary hypertension by the Na+/H+ exchange inhibitor amiloride.
11) In addition to sodium restriction, patients with grade 2 ascites (moderate ascites with proportionate abdominal distension) should receive a low-dose diuretic, such as spironolactone (initial dose, 50-100 mg/d; increase up to 200-300 mg/d) (13) or amiloride (5-10 mg/d).
The gene responsible for synthesizing DAO is amiloride binding protein 1 (ABP1), also known as amine oxidase, copper containing 1 (A0C1).
The samples contained amiloride and hydrochlorothiazide, which are both prohibited as diuretics and masking agents.