amidinotransferase

amidinotransferase

A family of enzymes that includes glycine and inosamine amidinotransferases, which are involved in creatine and streptomycin biosynthesis respectively. Amidinotransferases also includes arginine deiminases, which catalyse the reversible reaction: Arginine + H2O = Citrulline + NH3.
References in periodicals archive ?
It is well known that the transfer of the amidino group of arginine to glycine to yield L-ornithine and guanidinoacetate (GM), which is catalyzed by L-arginine:glycine amidinotransferase, represents the first of two steps in the biosynthesis of Cr.
For instance, among identified targets were titan and mitochondrial glycine amidinotransferase, two proteins known to occur in the low nanogram per milliliter range (4-6.
The antagonism between Arg and Lys significantly increases the activity of renal arginase and consequently induces Arg degradation (AUSTIC; SCOTT, 1975) and decreases the activity of glycine amidinotransferase, an enzyme that uses Arg and glycine as substrates with methionine in the synthesis of muscle creatine (JONES et al.
Arg transfers a guanidine group to glycine though the action of amidinotransferase, forming ornithine and guanidinoacetate.
14) Additional branches of arg metabolism are mediated by: (a) nitric oxide synthases (NOSs) leading to production of nitric oxide (NO) and downstream nitrogenous compounds, (b) arg decarboxylase leading to agmatine and its related byproducts, and (c) arg:glycine amidinotransferase leading to guanidinoacetic acid, the immediate precursor of creatine.
Guanidinoacetate and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate methyltransferase deficiencies.
In the current study, the gene encoding L-arginine-glycine amidinotransferase, a member of the creatinine biosynthesis pathway, was affected as early as the first day after treatment with cisplatin.
Biosynthesis involves two enzymes: L-arginine:glycine amidinotransferase (EC 2.
RNA samples representing single animals treated with cisplatin or gentamicin were also used to validate the expression profile of several genes identified using cDNA microarray data including osteopontin, inositol polyphospate multikinase, L-arginine glycine amidinotransferase, prosaposin, lipocalin, synaptogyrin 2, kallikrein, KIM-1, and an expressed sequence tag (EST) (GenBank accession no.
Arginine:glycine amidinotransferase (AGAT) is the enzyme responsible for the conversion of arginine and glycine into guanidinoacetate (GuAc) and ornithine in creatine biosynthesis.