amide local anesthetic

amide local anesthetic

any of the numerous compounds containing an amide chemical group that block nerve transmission. Amides are metabolized by microsomal P-450 enzymes in the liver. Examples of commonly administered amide local anesthetics are bupivacaine, lidocaine, and prilocaine.
References in periodicals archive ?
Tetracaine hydrochloride has a duration of action similar to that of the amino amide local anesthetic bupivacaine, both averaging 3 to 10 hours (13).
The other available amide local anesthetic agents, articaine, bupivacaine and mepivacaine, are all considered Category C drugs.
Articaine hydrochloride: a study of the safety of a new amide local anesthetic.
Comparative motor-blocking effects of bupivacaine and ropivacaine, a new amino amide local anesthetic, in the rat and dog.
Preservatives added to either the amide local anesthetic or its epinephrine additive are structurally similar to PABA and elicit adverse reactions similar to those triggered by the ester drugs.
In fact, in centers where the in vitro muscle contraction test is performed to test for malignant hyperthermia, physicians use the amide local anesthetic prilocaine.