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amide local anesthetic

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amide local anesthetic,
any of the numerous compounds containing an amide chemical group that block nerve transmission. Amides are metabolized by microsomal P-450 enzymes in the liver. Examples of commonly administered amide local anesthetics are bupivacaine, lidocaine, and prilocaine.


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The amide local anesthetic lidocaine was invented in the 1950s and it has been in use even till now due to its excellent anesthetic properties and little side effects.
In fact, in centers where the in vitro muscle contraction test is performed to test for malignant hyperthermia, physicians use the amide local anesthetic prilocaine.
 
 
 
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