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amidase

   Also found in: Encyclopedia 0.01 sec.
amidase /am·i·dase/ (am´ĭ-dās)
1. any of a group of enzymes that catalyze the cleavage of carbon–nitrogen bonds in amides.
2. an enzyme that catalyzes the cleavage of the carbon–nitrogen bond of a monocarboxylic acid amide to form a monocarboxylic acid and ammonia.

am·i·dase (m-ds, -dz)
n.
An enzyme that catalyzes the hydrolysis of monocarboxylic amides, thus freeing ammonia. Also called acylamidase, acylase.

amidase
[am′i·dās]
1 an enzyme that catalyzes the formation of a monocarboxylic acid and ammonia by hydrolytic cleavage of the C─N bond of a monocarboxylic acid amide.
2 a term used in the recommended and trivial names of some hydrolases acting on amides, particularly those acting on linear amides.


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This suggests that any CDEPA or CMEPA produced in this time was either not being metabolized to the corresponding aniline by the aryl amidase or metabolized so slowly as to preclude detection.
This toolbox is constantly expanding and includes all major classes of catalytic activities that are relevant for fine chemistry such as esterases, nitrilases, nitrile hydratases, amidases, epoxyde hydrolases, oxydo-reductases and many other ones" said Daniel Dupret, Chairman and CEO of Proteus.
Inhibitors of the amidase are under development using both the QCT(TM) and Oasis(TM) technologies.
 
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