ameloblastin


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ameloblastin

A minor protein of the enamel matrix encoded by AMBN on chromosome 4q21 that is expressed by ameloblasts during the differentiation of inner enamel epithelium, which may be a growth factor for periodontal ligament cells, facilitating their attachment. Ameloblastin modulates bone morphogenetic protein expression and downregulates collagen-1 expression.
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17) Among the secreted proteins are first those of the extracellular matrix (amelogenin, ameloblastin, and enamelin) and secondly the proteases: metalloproteinase matrix 20 (MMP-20) and kallikrein 4 (KLK-4).
19) The role of ameloblastin is less clear, but it has been found to have functions in the adhesion and control of ameloblasts differentiation.
47) In addition, concentrations of 120 [micro]M of F- reduce the expression of messengers of amelogenin, ameloblastin, enamelin, and MMP-20, as well as factors of vascularization, such as the endothelial growth factor (VEGF), monocyte chemoattractant proteins (MCP-1) and the interferon inducible protein (IP-10).
Our analysis showed amelogenin, ameloblastin, and enamelin--the latter more frequently in fluorotic enamel, suggesting a possible role of this protein in the events that trigger fluorosis--.
1 Organic part comprises proteins, mainly amelogenin, ameloblastin and tuftelin, with traces of proteoglycans and lipoids which mostly disappear upon enamel maturation.
A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression.
Genes implicated in autosomal forms are genes encoding enamel matrix proteins namely: enamelin and ameloblastin tuftelin MMP-20 and kallikrein 4.
Association between ameloblastin gene polymorphisms and the susceptibility to dental Fluorosis.
1 Similarly, an autosomal dominant, local hypoplastic form of AI, (AIH2) has been mapped to a 4mb region of human chromosome 4q11-q21 that encompasses the gene encoding the amleoblast specific protein ameloblastin, AMBN.
The major protein components of the enamel matrix include the most abundant amelogenin proteins as well as less plentiful proteins such as enamelin and ameloblastin.