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amelanotic

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amelanotic /amel·a·not·ic/ (a?mel-ah-not´ik) pertaining to or characterized by the absence of melanin.

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Although the tumor in our patient appeared to be amelanotic on clinical examination, melanin pigmentation was seen in the cytoplasm on microscopy, and immunohistology was positive for S-100 protein.
A patient with amelanotic melanoma may look well, but will likely soon be dead.
The differential diagnosis of dendritic reticulum cell sarcoma includes ectopic meningioma, ectopic thymoma, amelanotic malignant melanoma, malignant fibrous histiocytoma, and undifferentiated carcinoma.
 
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