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AMAZEA Multi-centre Trial Using ATACAND-ZESTRIL vs ZESTRIL to Evaluate the Effects on Lowering Blood Pressure. A clinical trial assessing the safety and tolerability of adding candesartan cilexetil to lisinopril rather than up-titrating lisinopril in hypertensive patients.
Conclusion For hypertensive patients not controlled by lisinopril (20 mg once daily), addition of candesartan (32 mg once daily) or doubling the dose of lisinopril provides safe, additional reduction of blood pressure.