amatoxin


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am·a·tox·in

(am-a-tok'sin),
One of a group of bicyclic octapeptides from death-cap fungus and deadly agaric (Amanita phalloides).

amatoxin

Toxicology Any of a family of potentially lethal toxins present in certain mushrooms—Amanita phalloides, Lepiota chlorophyllum and others, which may cause accidental poisoning in amateur mycophagists Clinical 12-hr latency, then N&V, abdominal pain, and diarrhea, which may be followed by an asymptomatic period before acute hepatic dysfunction and death Treatment Charcoal hemoperfusion

amatoxin

(am″ă-tok′sin) [ ama(nita) + toxin]
The chemical component of poisonous mushrooms that causes early onset of gastrointestinal upset. Liver failure follows about 36 hr later
References in periodicals archive ?
Administration of cimetidine, a cytochrome P-450 inhibitor which inhibits the uptake of amatoxins by the mixed function oxidase system, and N-acetylcysteine (NAC), a glutathione precursor that binds amatoxin-related free radicals, have also been used in the treatment of amanitin intoxication.
Indication of liver transplantation following amatoxin intoxication.
No correlation exists between the plasma amatoxin concentration and clinical outcome, nor does the amount of liver-bound toxin correlate with the plasma concentration.
Silymarine (from the milk thistle Silibum marianum) exerts its protective effect after intravenous administration in various ways: (a) by interrupting the enterohepatic recirculation of amanitin; (b) by inhibiting the binding of toxins to hepatocyte membranes; (c) by competing with amatoxin for transmembrane transport; and (d) by inhibiting the penetration of amanitin into liver cells (1).
Amatoxins, which constitute the second group of Amanita toxins, are cyclic octapeptides that interfere with DNA transcription (3).
3 mg/kg (8), and phallotoxins seem to exacerbate the action of amatoxins.