amantadine


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amantadine

 [ah-man´tah-dēn]
an antiviral compound used as the hydrochloride salt to treat influenza A; also used as an antidyskinetic in the treatment of parkinsonism and drug-induced extrapyramidal reactions.

amantadine

/aman·ta·dine/ (ah-man´tah-dēn) an antiviral compound used as the hydrochloride salt to treat influenza A; also used as an antidyskinetic in the treatment of parkinsonism and drug-induced extrapyramidal reactions.

amantadine

(ə-măn′tə-dēn′)
n.
A drug, C10H17, used in its hydrochloride form as an antiviral agent and treatment for Parkinson's disease.

amantadine

An antiviral agent that prevents the release of viral nucleic acid into the host cells, which is most effective against influenza virus; in parkinsonism, amantadine increases presynaptic dopamine release, blocks dopamine reuptake into the presynaptic neurons and has anticholinergic effects.
 
Adverse effects
Nausea, vertigo, confusion, hallucinations, anxiety, restlessness, depression, irritability, peripheral oedema, orthostatic hypotension, psychotic reaction.

Amantadine™

Therapeutics An antiviral that prevents the release of viral nucleic acid into the host cells, which is most effective against influenza virus; in parkinsonism, amantadine ↑ presynaptic dopamine release, blocks dopamine reuptake into the presynaptic neurons, and has anticholinergic effects Adverse effects Nausea, vertigo, confusion, hallucinations, anxiety, restlessness, depression, irritability, peripheral edema, orthostatic hypotension, psychotic reaction

amantadine

An antiviral drug, also used to treat PARKINSON'S DISEASE. Brand names are Lysovir and Symmetrel.

amantadine (əman´tidēn),

n an antiviral that prevents uncoating and replication of the influenza A virus; most effectively used in the early stages of exposure.
References in periodicals archive ?
The principal observation of this case was that the patient was found to be profoundly rigid on emergence from prolonged anaesthesia and responded rapidly to two cycles of treatment with Sinemet and one dose of amantadine administered via a nasogastric tube.
In human deaths have been reported from overdose with Amantadine.
Fatigue therapy in multiple sclerosis: results of a double blind, randomised parallel trial of amantadine, pemoline and placebo.
A double-blind, placebo-controlled, crossover study demonstrated a trend toward treatment benefit with a 6-week course of amantadine in the acute phase of severe TBI using outcome measures of Mini-Mental State Examination (MMSE), Glasgow Outcome Scale (GOS), and Disability Rating Scale (DRS) [26].
Suspected cases--treat with zanamivir alone or with a combination of oseltamivir and either amantadine or ramantadine at the onset of symptoms and for a duration of 5 days
Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats.
Amantadine inhibits an early step in the viral replication process, probably viral uncoating, and also has an effect on one of the final steps of viral assembly in some strains.
Meanwhile, the Health, Labor and Welfare Ministry said the same day that there have been 16 reports of abnormal behavior by people who took two other anti-influenza agents, Relenza and Amantadine.
Amantadine is not available in the National Antiviral Stockpile and its use is not recommended during a pandemic.
Small studies of amantadine produced mixed results; some showed no beneficial effects while others did.
These factors, together with the routine use of antibiotics and Amantadine (a human anti-flu drug) in feed, will ensure drug-resistant strains.
Although ion channel inhibitors, such as amantadine, are effective against several strains of flu viruses, their side effects mean they are not being widely stockpiled, the experts said.