Partial inhibition with amanitin
influences tumor cell--but not normal cell--activity.
Amanitin poisoning is distinguished bythree clinical stages: an incubation stage, a gastrointestinal stage and a cytotoxic stage.
Administration of cimetidine, a cytochrome P-450 inhibitor which inhibits the uptake of amatoxins by the mixed function oxidase system, and N-acetylcysteine (NAC), a glutathione precursor that binds amatoxin-related free radicals, have also been used in the treatment of amanitin intoxication.
Molecular characterization and inhibition of amanitin uptake into human hepatocytes.
While detection of amanitins is important in the diagnosis, there is no correlation between plasma concentration and clinical outcome.
duzeyi ile karaciger hasarinin agirligi arasinda korelasyon gosterilememistir ve amanitin
duzeyinin prognoz acisindan degeri olmadigi bildirilmektedir (19).
Its killer poison, amanitin
, damages the liver and kidneys.
arms and amanitin
, radioactive sustenance, high explosive, currency and mint, security printing and alcohol beverages.
This book contains a section on amanitin
, the major toxin for this class of mushroom.
Silymarine (from the milk thistle Silibum marianum) exerts its protective effect after intravenous administration in various ways: (a) by interrupting the enterohepatic recirculation of amanitin; (b) by inhibiting the binding of toxins to hepatocyte membranes; (c) by competing with amatoxin for transmembrane transport; and (d) by inhibiting the penetration of amanitin into liver cells (1).
Methods for chromatographic determination of amanitins and related toxins in biological samples.