alveolar rhabdomyosarcoma


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Related to alveolar rhabdomyosarcoma: embryonal rhabdomyosarcoma

alveolar rhabdomyosarcoma

An aggressive rhabdomyosarcoma that arises in the extremities, pelvis, and trunk of children to young adults (10 to 25).
DiffDx Ewing sarcoma, melanoma, neuroblastoma.
Prognosis Poor; metastasises to lungs and regional lymph nodes. Alveolar RMS’s bad behaviour (compared to embryonal RMS) is attributed to the t(2;13) translocation.
References in periodicals archive ?
Consistent chromosomal translocation in alveolar rhabdomyosarcoma.
Alveolar rhabdomyosarcoma with the t(2;13): cytogenetic findings and clinicopathologic correlations.
Importantly, because roughly 20% of alveolar rhabdomyosarcomas do not harbor rearrangements of FOXO1A (5-8) (30% in our study), a negative FOXO1A FISH study does not exclude the diagnosis of alveolar rhabdomyosarcoma; in these cases, the diagnosis rests upon recognition of characteristic histologic features and a supportive immunohistochemical profile.
For example, alveolar rhabdomyosarcoma has been shown to portend a poorer prognosis than embryonal rhabdomyosarcoma, and different therapeutic approaches for these 2 entities have been suggested.
That was on May 3, 2007, that day the young couple were told the heartbreaking news that Ethan's tumour was cancerous and that he had the extremely rare, and highly aggressive, paratesticular alveolar rhabdomyosarcoma.
Possible diagnoses entertained included Ewing sarcoma/primitive neuroectodermal tumor, alveolar rhabdomyosarcoma, extraskeletal myxoid chondrosarcoma, epithelioid sarcoma, poorly differentiated synovial sarcoma, DSRCT, and unusual examples of leiomyoma, leiomyosarcoma, and various ovarian or myoepithelial tumors.
Of the aforementioned diagnostic considerations for the current case, alveolar rhabdomyosarcoma, extraskeletal myxoid chondrosarcoma, epithelioid sarcoma, myoepithelial tumors, and DSRCT may all demonstrate polyphenotypic immunohistochemical profiles.
The eight-year-old, who suffers from the rare cancer alveolar rhabdomyosarcoma, has lost her hair due to the intensive chemotherapy course she has endured.
In these cases, the differential diagnosis has to be made with alveolar sarcoma, fibrous malignant histiocytoma, alveolar rhabdomyosarcoma, liposarcoma, variant of malignant melanoma, and some large carcinomatous metastases (especially from kidney, thyroid, adrenal medulla, and liver).
Rebecca, from Billingham, and her family found out the news that the little girl had a rare cancer - alveolar rhabdomyosarcoma - in February after she was taken to hospital with a swollen leg.
Alveolar rhabdomyosarcoma is more usual in older children or teens.
The youngster, a pupil at Bewley Primary School, was instantly referred to Newcastle's RVI to begin an intensive course of treatment after being diagnosed with alveolar rhabdomyosarcoma.