alveolar macrophage


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al·ve·o·lar mac·ro·phage

a vigorously phagocytic macrophage on the epithelial surface of lung alveoli where it ingests inhaled particulate matter.
Synonym(s): coniophage, dust cell

alveolar macrophage

a cell of the reticuloendothelial system in the lungs that engulfs and digests foreign substances inhaled into the alveoli.

alveolar macrophage

A free mononuclear cell of the lower respiratory tract, which has a high phagocytic capacity and is responsible for clearing inhaled particles and lung surfactant. Alveolar macrophages (AMss,  are transiently attached by pseudopodia to the surface of alveolar epithelium. Presence of AMs in sputum submitted for cytologic evaluation are markers of specimen adequacy. AMs are generally submerged in a film of phospholipids, and thus form part of the surface lining of the aveoli.

alveolar macrophage

Physiology A free mononuclear cell of the lower respiratory tract, which has a high phagocytic capacity, and is responsible for clearing inhaled particles and lung surfactant; AMs are transiently attached by pseudopodia to the surface of alveolar epithelium; presence of AMs in sputum submitted for cytologic evaluation are markers of specimen adequacy; AMs are generally submerged in a film of phospholipids, and thus form part of the surface lining of the aveoli See Dust cell, Dust macule.

al·ve·o·lar mac·ro·phage

(al-vē'ŏ-lăr mak'rō-fāj)
A vigorously phagocytic macrophage on the epithelial surface of lung alveoli where it ingests inhaled particulate matter.
Synonym(s): coniophage, dust cell.

al·ve·o·lar mac·ro·phage

(al-vē'ŏ-lăr mak'rō-fāj)
A vigorously phagocytic macrophage on the epithelial surface of lung alveoli where it ingests inhaled particulate matter.
Synonym(s): coniophage, dust cell.
References in periodicals archive ?
The speculation is alveolar macrophages deposit them there as the macrophages transport asbestos fibers through the lymphatic system after phagocytizing them in the alveoli.
Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage.
Mechanical ventilation exacerbates alveolar macrophage dysfunction in the lungs of ethanol-fed rats.
Human alveolar macrophages were obtained from recruited healthy nonsmoking subjects (age 20-40, equally divided between males and females).
Marijuana and cocaine impair alveolar macrophage function and cytokine production.
2000) Role of pulmonary alveolar macrophages in defense of the lung against Pseudomonas aeruginosa.
Although acute lung inflammation (ALI) caused by CS exposure does not model all aspects of COPD pathogenesis, the two processes do share certain hallmarks, including accumulation of inflammatory cells such as alveolar macrophages and neutrophils, and lung oxidative stress (Silva Bezerra et al.
This study revealed novel effects of cigarette smoking on alveolar macrophage physiological functions which could contribute to lung bacterial colonization by opportunistic pathogens, such as NTHI," said the researchers.
We examined the transcription level of IL-1[beta] and IL-18 and found that IL-1[beta] mRNA in alveolar macrophages was up-regulated at 6 hr, and this level remained at a similar level throughout the 72-hr time course (Figure 1F).
In this study, we investigated P quinquefolius' immunostimulating activity in vitro by testing the ability of alveolar macrophages (AM) to produce tumour necrosis factor alpha (TNF) in response to different extracts of P.
mice at baseline and suggested that low levels of alveolar macrophage costimulatory molecule expression are maintained at least in part by endogenous IL-10 activity.
Environmental exposures may cause alveolar macrophage impairment due to the presence of dusts or crystals, such as in PAP due to silico sis.