alternating hemiplegia of childhood

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alternating hemiplegia of childhood

A rare (1:106) idiopathic condition characterised by transient attacks of hemiplegia, ranging in severity from mild weakness to complete uni- or (less commonly) bilateral paralysis.

• Avoid triggers—e.g., temperature changes, water exposure, bright lights, certain foods, emotional stress, physical activity.
• Flunarizine (calcium channel blocker), benzodiazepines, anti-epileptics.

Poor with cognitive impairment, behavioural and psychiatric disorders, and various motor defects.

Molecular pathology
Some cases have an ATP1A2 mutation.

Alternating hemiplegia of childhood, diagnostic criteria
• Onset before 18 months of age;
• Attacks of both hemiplegia on either side of the body;
• Other autonomic problems—e.g., episodic monocular nystagmus, (improper eye alignment), choreoathetosis;
• Sustained muscle contractions (dystonia);
• Mental retardation, delayed development and other neurological abnormalities;
• Symptoms disappear when sleeping;
• Episodes of bilateral hemiplegia that shift from one side of the body to the other.
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References in periodicals archive ?
A few months later his life was turned upside down when he was diagnosed with Alternating Hemiplegia of childhood (AHC,) suffering excessive amounts of seizures and paralysis, and ending up in a coma.
Youngsters with alternating hemiplegia of childhood suffer seizures brought on by different individual triggers - water, exercise, light, food or even strong perfume.
It was only after the family, including mum Helen, 50, and Alex, 51, took Callum on a break to Wooler, Northumberland, and he suffered a major attack that he was finally diagnosed with alternating hemiplegia of childhood, (AHC), a rare neurological disorder that can leave sufferers paralysed.
The six year-old suffers from Alternating Hemiplegia of Childhood, a rare neurological disorder which causes temporary paralysis in one or both sides of his body.
Callum's family also expressed frustration at the lack of research going into Alternating Hemiplegia of Childhood, the one-in-amillion condition which has shattered her son's life.

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