Alstonine is the major component of plant based remedies that traditional psychiatrists use in Nigeria.
If proven, the apparent lack of D2R blockade by alstonine would represent an innovative pharmacodynamic basis for antipsychotic properties.
Alstonine Isolation and Identification: Alstonine (hydrochloride) was isolated from the rinds of Picralima nitida (Stapf) T.
2] and further incubated for 1 h in the same buffer with added clozapine (10 or 100 /zM) or alstonine (10 or 100 [micro]M) plus 1.
Alstonine (10 and 100 [micro]M) did not modify [[sup.
5 mg/kg) alstonine increased synaptosomal dopamine uptake ([F.
The data obtained in this study corroborate our previous hypothesis that alstonine does not bind to D2R because the QAR data clearly demonstrate that alstonine does not bind to D2R.
Another important finding in this study is that in mice treated with alstonine, there was a two-fold increase in striatal DA uptake, which is correlated with the dose and timing of the antipsychotic-like effects of alstonine in mice models of positive symptoms (Costa-Campos et al.
The consistent antipsychotic profile of alstonine in mice, as well as the therapeutic outcomes alleged by traditional Nigerian psychiatrists, requires that the mechanism of dopamine pathway modulation be clarified.
Alstonine is present in Rauwolfia species such as Rauwolfia caffra Sond.
its uses demonstrates US20090247495 (2009) methods for preventing or treating various disorders by administering compounds consisting cucurbitacin A Flavopereirine and This invention 2009/ Hail and alstonine presents a method US20090215853 Beljanski cocktails in the for administration (2009) of treatment and an effective dose prevention of of a cocktail of prostate cancer flavopereirine and alstonine for preventing prostate cancer and/or decreasing PSA levels.
Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer, US20090215853.