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ALPINEAntihypertensive Treatment & Lipid Profile in a North of Sweden Efficacy Evaluation. A clinical trial comparing long-term (1-year) low-dose diuretic (hydrochlorothiazide, or HCTZ, ± a beta-blocker, atenolol), to an angiotensin II type 1 receptor blocker (candesartan ± a calcium antagonist, felodipine), in newly diagnosed hypertensives.
Conclusion Metabolic changes and adverse effects were reduced with candesartan.