alpha1-antitrypsin

(redirected from alpha1-trypsin inhibitor)

α1-an·ti·tryp·sin

A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein. The concentration of α1-antitrypsin increases in response to injury or infection. α1-Antitrypsin also inhibits thrombin and elastase.

alpha1-antitrypsin

/al·pha1-an·ti·tryp·sin/ (-an″tĭ-trip´sin) a plasma α1-globulin produced primarily in the liver; it inhibits the activity of elastase, cathepsin G, trypsin, and other proteolytic enzymes. Deficiency is associated with development of emphysema.

α1-antitrypsin

/α1-an·ti·tryp·sin/ (-trip´sin) alpha.

alpha1-antitrypsin

Etymology: Gk, anti, against, trypsin
a plasma protein produced in the liver that inhibits the action of proteolytic enzymes such as trypsin. Deficiencies are associated with liver disease in children and panacinar emphysema in adults. In the latter, the basic lesion is believed to result from effects of proteolytic enzymes on the walls of the alveoli. Also called antitrypsin, alpha1-proteinase inhibitor.

α1-an·ti·tryp·sin

(an'tē-trip'sin)
A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein.

alpha1-antitrypsin

a plasma protein (α1-globulin) produced in the liver, which inhibits the activity of trypsin and other proteolytic enzymes. Deficiency of this protein is associated with round heart disease in turkeys. Called also α1-protease inhibitor.

alpha1-antitrypsin mastitis test
after the first month of lactation, it is an indication of leakage through damaged endothelium.