alpha1-antitrypsin

α1-an·ti·tryp·sin

A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein. The concentration of α1-antitrypsin increases in response to injury or infection. α1-Antitrypsin also inhibits thrombin and elastase.

alpha1-antitrypsin

/al·pha1-an·ti·tryp·sin/ (-an″tĭ-trip´sin) a plasma α1-globulin produced primarily in the liver; it inhibits the activity of elastase, cathepsin G, trypsin, and other proteolytic enzymes. Deficiency is associated with development of emphysema.

α1-antitrypsin

/α1-an·ti·tryp·sin/ (-trip´sin) alpha.

alpha1-antitrypsin

Etymology: Gk, anti, against, trypsin
a plasma protein produced in the liver that inhibits the action of proteolytic enzymes such as trypsin. Deficiencies are associated with liver disease in children and panacinar emphysema in adults. In the latter, the basic lesion is believed to result from effects of proteolytic enzymes on the walls of the alveoli. Also called antitrypsin, alpha1-proteinase inhibitor.

α1-an·ti·tryp·sin

(an'tē-trip'sin)
A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein.

alpha1-antitrypsin

a plasma protein (α1-globulin) produced in the liver, which inhibits the activity of trypsin and other proteolytic enzymes. Deficiency of this protein is associated with round heart disease in turkeys. Called also α1-protease inhibitor.

alpha1-antitrypsin mastitis test
after the first month of lactation, it is an indication of leakage through damaged endothelium.
References in periodicals archive ?
Alpha1-antitrypsin, an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro [27].
Awards fund early career investigators' research to advance understanding and treatment of alpha1-antitrypsin deficiency.
Awards fund early-career investigators' research to advance understanding and treatment of alpha1-antitrypsin deficiency
2002) Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1antichymotrypsin.
to support research into alpha1-antitrypsin deficiency, a genetic condition in which low levels of the essential blood protein alpha1-proteinase inhibitor, can cause emphysema.
Alpha1-antitrypsin deficiency--a model for conformational diseases.
San Carlos, CA; 650-631-3138), a pioneer in drug delivery technology solutions, announced that Aventis has received Orphan Medicinal Product Designation from the European Commission for the inhaleable form of Alpha1-Antitrypsin (Human), currently in clinical trials for the treatment of hereditary emphysema.
Some 25 years later, however, he was suffering from end-stage emphysema resulting from alpha1-antitrypsin ([A.
Abnormalities in the alpha1-antitrypsin may indicate the presence of lung and/or liver disease in children and adults.
When there is a shortage of the liver-produced blood protein called alpha1-antitrypsin, elastase is free to attack the connective tissue in alveolar walls.
Zemaira is indicated for chronic augmentation and maintenance therapy in individuals with alpha1-antitrypsin (AAT) deficiency and clinical evidence of emphysema.

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