alpha-lipoic acid


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alpha-lipoic acid

A naturally occurring compound synthesised in small amounts by humans, which is regarded by some authors as a conditionally essential nutrient. It is an antioxidant and may have several roles in the body, such as the chelation of metals (cadmium, copper, iron, lead, mercury and others) and extraction of energy from food. Alpha-lipoic acid is said be effective in treating cardiovascular disease, diabetes mellitus (by preventing glycation), strokes, gangrene, Alzheimer’s disease, Parkinson’s disease and retinal degeneration.
 
The body of peer-reviewed data is limited, but suggests that intravenous lipoic acid may improve peripheral neuropathy in diabetics.

alpha-lipoic acid

C8H14O2S2, a natural coenzyme and antioxidant, used for short-term treatment of peripheral neuropathies.
CAS # 1200-22-2
See also: acid
References in periodicals archive ?
Effects of alpha-lipoic acid supplementation on antioxidative ability and performance of sows and nursing piglets.
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.
The panel found moderate evidence for the use of capsaicin and isosorbide dinitrate spray (level B), weak evidence for the Lidoderm patch (level C), and insufficient evidence to support or refute the usefulness of vitamins and alpha-lipoic acid (level U).
The critical job of alpha-lipoic acid in brain cells is to stand guard over the mitochondrial energy plants, protecting them against damage from the continual onslaught of free radical chemicals.
Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro.
For example, for the treatment of diabetes, the author suggests intakes for chromium, co-enzyme Q10, vitamin C, flavonoids, vitamins E, B6, B12, biotin, B2, D, as well as magnesium, zinc, inositol, alpha-lipoic acid, carnitine and evening primrose oil.
Specifically, alpha-lipoic acid, vitamin C and trivalent chromium (as in the form chromium picolinate) are thought to be preventative.
Q I HAVE taken alpha-lipoic acid and l-carnitine for three months to reduce forgetfulness.
I have found considerable relief taking a supplement called alpha-lipoic acid 250 mg per day.
In addition, Revatrol provides three anti-aging antioxidants in the supplement's formula including: 100MG of Alpha-Lipoic Acid, 100MG of Acetyl L-Carnitine and 100MG of Quercetin.
3 g per day of eicosapentaenoic acid (EPA), 300 mg per day of alpha-lipoic acid (ALA), both treatments, or placebo for 10 weeks.
Alpha-lipoic acid (LA) and its reduced form, dihydrolipoic acid (DHLA), have received widespread attention as antioxidants with both preventative and therapeutic uses in humans and laboratory animals.