alpha-lipoic acid


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alpha-lipoic acid

A naturally occurring compound synthesised in small amounts by humans, which is regarded by some authors as a conditionally essential nutrient. It is an antioxidant and may have several roles in the body, such as the chelation of metals (cadmium, copper, iron, lead, mercury and others) and extraction of energy from food. Alpha-lipoic acid is said be effective in treating cardiovascular disease, diabetes mellitus (by preventing glycation), strokes, gangrene, Alzheimer’s disease, Parkinson’s disease and retinal degeneration.
 
The body of peer-reviewed data is limited, but suggests that intravenous lipoic acid may improve peripheral neuropathy in diabetics.

alpha-lipoic acid

C8H14O2S2, a natural coenzyme and antioxidant, used for short-term treatment of peripheral neuropathies.
CAS # 1200-22-2
See also: acid
References in periodicals archive ?
Alpha-lipoic acid regulates heme oxygenase gene expression and nuclear Nrf2 activation as a mechanism of protection against arsenic exposure in HepG2 cells.
Comparison of the effect of alpha-lipoic acid and alphatocopherol supplementation on measures of oxidative stress.
Burning mouth syndrome: open trial of psychotherapy alone, medication with alpha-lipoic acid (thioctic acid), and combination therapy.
In humans, alpha-lipoic acid has been shown to help lower blood pressure, blood sugar, and triglycerides; reverse insulin resistance; and prevent diabetic neuropathy.
Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers.
Studies show that topical application of alpha-lipoic acid provides antioxidant and anti-inflammatory protection that can improve the appearance of aging skin damaged by exposure to the sun.
Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients.
Specifically, alpha-lipoic acid, vitamin C and trivalent chromium (as in the form chromium picolinate) are thought to be preventative.
I have found considerable relief taking a supplement called alpha-lipoic acid 250 mg per day.
SAN FRANCISCO -- Headline and sub-head of release should read: Controlled-Release Alpha-Lipoic Acid Introduced for Diabetics; The First and Only Proprietary, Controlled-Release Formulation of Alpha-Lipoic Acid Reduces Oxidative Stress Associated with Diabetes by Antagonizing Excessive Free Radicals at the Cellular Level (sted First-Ever Controlled-Release Alpha-Lipoic Acid Helps Relieve Diabetic Complications; Medical Research Institute Introduces Glucotize: First and Only Controlled-Release Formulation of Alpha-Lipoic Acid; Shown to Help Reduce Oxidative Stress Associated with Diabetes at Cellular Level).
An article published in Cell Reports reveals a protective effect for supplementation with alpha-lipoic acid on telomere length and vascular health in mice given a high-fat diet.
3 g per day of eicosapentaenoic acid (EPA), 300 mg per day of alpha-lipoic acid (ALA), both treatments, or placebo for 10 weeks.