The mutated lymphoma cell displays a deficiency of a metabolite called alpha-ketoglutarate
(α-KG), which is needed in steady levels for cells to be healthy.
Campbell B, Roberts M, Kerksick C, Wilborn C, Marcello B, Taylor L, Nassar E, Leutholtz B, Bowden R, Rasmussen C et al (2006) Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.
Little JP, Forbes SC, Candow DG, Cornish SM, Chilibeck PD (2008) Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance.
Hammarqvist F, Wernerman J, von der Decken A, Vinnars E (1991) Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery.
A naturally occurring cofactor for the mitochondrial enzymes pyruvate dehydrogenase and alpha-ketoglutarate
dehydrogenase, LA has been shown to have a variety of properties which can interfere with the pathogenesis or progression of AD.
Zn2+ inhibits alpha-ketoglutarate
-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate
Additional research may look at arginine and alpha-ketoglutarate
based on their role in nitric oxide (NO) production, as well as beta-alanine and functional sugars, such as tagatose and trehalose.
Pharmokinetic Profile of Time Released and Non-Time Released Oral Arginine," "Effects Of Arginine Alpha-Ketoglutarate
Supplementation on Body Composition and Training Adaptations," "Effects of Arginine Alpha-Ketoglutarate
Supplementation on Markers of Catabolism and Health Status" and "Effects of Arginine Alpha-Ketoglutarate
Supplementation on Quality of Life.
40) R-alpha lipoic acid is a naturally occurring cofactor for the mitochondrial enzymes pyruvate dehydrogenase and alpha-ketoglutarate