SGCA

(redirected from alpha-SG)

SGCA

A gene on chromosome 17q21 that encodes a component of the dystrophin-glycoprotein complex, which is thought to be restricted to striated muscle. It stabilises muscle cell membranes and links the actin cytoskeleton to the extracellular matrix.

Molecular pathology
SGCA mutations result in type 2D autosomal recessive limb-girdle muscular dystrophy.
References in periodicals archive ?
The volunteers were evaluated at set intervals through 180 days, and therapy effectiveness was measured by assessing alpha-SG protein expression in the muscle, which was four to five times higher than in the muscles that received only the saline.
During the trial, the researchers evaluated the safety of a modified adeno-associated virus - an apparently harmless virus known as AAV that already exists in most people - as a vector to deliver the alpha-SG gene to muscle tissue.
The team evaluated the volunteers at set intervals through 180 days, and measured the therapy's effectiveness by assessing alpha-SG protein expression in the muscle, which was four to five times higher than in the muscles that received only the saline.