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alpha-L-iduronidase

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alpha-L-iduronidase
deficiency of the enzyme considered to be counterpart of mucopolysaccharidosis in cats and dogs; a neuronal storage disease.


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Infusions of manufactured alpha-L-iduronidase can ameliorate some symptoms but probably don't penetrate the blood-brain barrier and therefore don't prevent brain damage, says study coauthor Joanne Kurtzberg, a pediatric oncologist at Duke University Medical Center in Durham, N.
Cambridge, MA) announced the issuance of a third United States patent involving the lysosomal enzyme alpha-L-iduronidase (IDUA), which is deficient in persons suffering from mucopolysaccharidosis type I (MPS I), also referred to as Hurler syndrome, Hurler-Scheie syndrome, or Scheie syndrome.
Aldurazyme (laronidase) is an enzyme replacement therapy for the treatment of mucopolysaccharidosis I (MPS I), a rare, progressive and debilitating genetic disorder caused by a deficiency of the enzyme alpha-L-iduronidase.
 
 
 
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