ADRA1A

(redirected from alpha-1A adrenergic receptor)

ADRA1A

A gene on chromosome 8p21.2 that encodes alpha-1A-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which activates a phosphatidylinositol-calcium second messenger system, triggering mitogenic responses and regulating growth, proliferation and signalling through the Gq/11 family of G proteins. ADRA1A is also an older gene name for what is formally known as ADRA1D, see there.
References in periodicals archive ?
10:40 ALPHA-1A ADRENERGIC RECEPTOR ACTIVATION ENHANCES NEUROGENESIS
patents covering the alpha-1a adrenergic receptor and the use of selective alpha-1a antagonists for the treatment of BPH.
Synaptic has been issued United States patents covering the alpha-1a adrenergic receptor and the use of selective alpha-1a antagonists for the treatment of benign prostatic hypertrophy.
In September 1999, Synaptic announced that Merck, in a phase IIa clinical trial involving a selective alpha-1a antagonist, had successfully validated Synaptic's proprietary alpha-1a adrenergic receptor as a target for BPH, but had discontinued development of the compound due to limited oral bioavailability and the potential for drug interactions.
The joint research program between Synaptic and Merck is focused on the development of compounds that selectively block the human alpha-1a adrenergic receptor for the treatment of BPH.
engineered cells expressing the human alpha-1a adrenergic receptor to
Recent studies have suggested that alpha-1A adrenergic receptors ([alpha]1A-ARs) may regulate neurogenesis and neuronal differentiation (1, 2).
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