allylamine


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al·lyl·a·mine

(al'il-ā-mēn'),
Member of a class of antifungal agents that works by inhibiting squalene epoxidase, an enzyme involved in the synthesis of ergosterol, a component of fungal cell walls.

allylamine

a group of fungicidal drugs which disrupt fungal cell wall formation, by inhibiting squalene epioxase activity (see terbinafine)
References in periodicals archive ?
Naftifine is an allylamine drug, and is mainly an antidermatophyte agent --albeit a "very, very potent antidermatophyte" --with no antibacterial activity, she said.
For this reason, aminolysis reactions of waste PET have been carried out using different amines such as allylamine, morpholine, hydrazine benzylamine, ethylenediamine, hexamethylenediamine, piperidine, aniline, and polyamines (25), (26).
Naftifine hydrochloride (naftifine) is a topical antifungal of the allylamine class, displaying fungicidal and fungistatic activity.
Terbinafine hydrochloride is a relatively new allylamine with a broad range of in vitro antifungal activity.
Background and Objective: N-(1-naphthylmethyl)amine is an important intermediate in the synthesis of biologically active compounds, including allylamine fungicides, such as naftifine, terbinafine, and butenafine.
Although the allylamine terbinafine is not used for treatment of patients with invasive aspergillosis, the drug is highly active against both E.
Posaconazole, a new broad-spectrum triazole, and terbinafine, an allylamine antifungal, have in vitro activity against these fungi.
Pat Mastin, chief of the NIEHS Cellular, Organ, and Systems Pathobiology Branch, points out that several occupational exposures also have been associated with CVD, including exposures to vinyl chloride (used to produce polyvinyl chloride and industrial solvents), carbon monoxide (a common exhaust gas), and allylamine (used in ion exchange resins, pharmaceuticals, and water-soluble polymers).
1), a synthetic allylamine antifungal agent, was used as the combination partner, since it is the preferred antifungal drug to treat mycoses produced by dermatophytes (Gokhale and Kulkarni 2000).
Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.
This article is continuation of that work and reports UV surface grafting of WGRT powder with allylamine.
Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.