alloxan


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to alloxan: streptozotocin

al·lox·an

(ă-loks'-an),
An oxidation product of uric acid, 2,4,5,6-pyrimidinetetrone; administration to experimental animals causes hypoglycemia resulting from insulin liberation, followed by hyperglycemia resulting from destruction of the islets of Langerhans (alloxan diabetes).

alloxan

/al·lox·an/ (ah-lok´san) an oxidized product of uric acid that tends to destroy the islet cells of the pancreas, thus producing diabetes (alloxan diabetes).

alloxan

[əlok′san]
an oxidation product of uric acid that is found in the human intestine in diarrhea. Alloxan has been used to produce diabetes in experimental animals by destroying the insulin-secreting islet cells of the pancreas.

alloxan

An oxygenated pyrimidine derivative, which is a toxic glucose analogue that induces experimental diabetes by selectively destroying pancreatic beta cells by superoxide production.

al·lox·an

(AX) (ă-loks'an)
An oxidation product of uric acid.

alloxan (əlok´san),

n a substance, mesoxalyl urea, capable of producing experimental diabetes by destroying the islet cells of the pancreas.

alloxan

an oxidized product of uric acid which destroys β cells of the islets of Langerhans in the pancreas. It has been used in experimental studies of diabetes mellitus and in the treatment of insulinomas in dogs.
References in periodicals archive ?
Animals having fasting blood glucose more than 250mg/dl, 3 days after alloxan injection, were included in the diabetic groups.
Protocol to Induce Diabetes by Alloxan Monohydrate: Diabetes was induced in mice according to Bukhari et.
14***) on third day after alloxan injection as compared to normal animals (100.
However reduction in plasma glucose levels in our study was greater, which might be due to the fact that our study was conducted in Sprague-Dawley rats as compared to mice used in research work done by Parmar and Kar9 and also the method of induction of diabetes used in present study was differet from the alloxan used by Parmar and Kar9 for induction of diabetes.
Antihyperglycemic and antihyperlipidemic effects of different fractions of Stevia rebaudiana leaves in alloxan induced diabetic rats.
60 male Wistar rats of 300 to 320 g in weight underwent a dose of 150 mg/kg of alloxan intraperitoneally.
Study of antihyperglycemic effect of Catharanthus roseus in alloxan induced diabetic rats.
Antidiabetic activity of SALE was assessed in normal, glucose loaded and alloxan induced diabetic mice.
Rapid intracelular acidification and cell death by H2O2 and alloxan in pancreatic s cells.