allotype


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Related to allotype: idiotype

al·lo·type

(al'ō-tīp),
Any one of the genetically determined antigenic differences within an immunoglobulin isotope that occur among members of the same species.
See also: antibody.
Synonym(s): allotypic marker
[allo- + G. typos, model]

allotype

/al·lo·type/ (al´o-tīp) any of several allelic variants of a protein that are characterized by antigenic differences.alloty´pic

allotype

(ăl′ə-tīp′)
n.
1. A biological specimen that is the opposite sex of a holotype.
2. Immunology Any of the alleles in the constant region of a given subclass of immunoglobulin that are detectable as antigens by members of the same species having a different constant region.

al′lo·typ′ic (-tĭp′ĭk) adj.
al′lo·ty′py (-tī′pē) n.

allotype

Immunology
An inherited set of determinants or sequence of amino acids (e.g., on an immunoglobulin—Ig) and other proteins demonstrating heterogeneity, which is specific for an individual and more common in a racial group.

In humans, Ig light-chain allotypes are designated as Km (Inv) allotypes and heavy-chain allotypes as Gm allotypes.

Molecular biology
A protein or other biomolecular variant arising from genetic differences between individuals of the same species.

allotype

An inherited set of determinants or sequence of amino acids–eg, on an Ig–and other proteins demonstrating heterogeneity, which is specific for an individual and more common in a racial group. Cf Idiotype, Isotype.

al·lo·type

(al'ō-tīp)
Any one of the genetically determined antigenic differences within a given class of immunoglobulin that occur among members of the same species.
See also: antibody
[allo- + G. typos, model]

allotype

An allelic variant of an antigen which can prove immunogenic in people with a different version of the allele.

allotype

An allelic variant of an ANTIGEN. Such a variant may elicit an immune response in an apparently normal person.

allotype

one of a range of ANTIBODIES containing different sequences of amino acids but all having an area with an identical amino acid sequence and thought to be produced by different alleles of the same gene (see MULTIPLE ALLELISM).

allotype

a genetically determined variation in plasma proteins which may be recognized as antigenic by other members of the same species. Commonly applied to subclasses of immunoglobulins.
References in periodicals archive ?
To investigate the basis for the suggested interindividual genetic susceptibility to CBD, we constructed three-dimensional structural models of HLA-DP representing several distinct allotypes and calculated the electrostatic potential on the surface of these models.
1 M 4 F holotype, allotype and paratypes Gatlinburg, sifting leaves near the river, Tennessee.
et al: Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with Km(1) immunoglobulin allotype.
Shih Chung-Kun, Infineum Beijing, for kindly presenting the allotype specimen of Patarchaea for study.
The presence of the ccrAB gene complex allotype 4 (ccr complex 4) was assessed in a separate reaction that used the primer pair ccrA4F and ccrB4R (27).
The G2m(n) allotype of IgG2 has been associated with increased susceptibility to infections with encapsulated bacteria (5).
HOLOTYPE [male] and ALLOTYPE [female] labeled: "PANAMA: Veraguas, Cerro Hoya, 1-6-VI-2008, Alt.
The holotype male specimen of this new species is the allotype (paratype) of Selenocosmia huwena by Wang, Peng & Xie (1993).
Real-time PCR with allotype and the intensity of infection by genotype.