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allostery

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allostery /al·lo·ste·ry/ (al´o-ster″e) the condition in which binding of a substrate, product, or other effector to a subunit of a multi-subunit enzyme at a site (allosteric site) other than the functional site alters its conformation and functional properties.


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In the present study allostery was revealed in the protein kinase A catalysed reaction of peptide phosphorylation, and the effect was quantified in terms of the interaction factor [alpha] for seven substrates.
Importantly, an action in one domain could affect other, distally located sites, an event termed allostery (Kern and Zuiderweg 2004).
This property is allostery, and a protein is allosteric if it can increase or decrease its ability to participate in a reaction.
 
 
 
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